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Serotonin has been implicated in several canine diseases, including myxomatous mitral valve disease, pulmonary hypertension and dilated cardiomyopathy, but direct measurement in blood is challenging because of its short half-life in serum.
In humans, urinary 5‑HIAA is considered a more accurate marker of serum serotonin concentration.
However, whilst urine 5-HIAA has previously been measured in dogs using gas chromatography mass spectrometry and high-performance liquid chromatography with electrochemical detection, these techniques are expensive and not widely available.
For the study, which was funded by BSAVA PetSavers and published in the Journal of Small Animal Practice, researchers collected urine samples from 26 dogs undergoing routine diagnostic evaluation at a referral hospital.
Each sample was analysed using both a commercially available ELISA testing kit, BA-E-1900 from Immusmol, and liquid chromatography-tandem mass spectrometry, the current gold standard method.
The ELISA was found to be reliable with acceptable precision and repeatability, particularly at low concentrations, although it had a slightly higher observed error at higher concentrations.
The researchers recommended further validation work to improve understanding of the various preanalytical factors that may influence measurement of 5-HIAA concentrations.
They also said further work should investigate whether measuring urinary 5-HIAA will be a good surrogate marker for physiologically active circulating serotonin in dogs, and whether it will be useful in studying disease pathogenesis.
Dr Penny Watson, senior author of the study, said: "I am very hopeful that, after further validation, this ELISA will prove to be a reliable, simple and cheap test for 5-HIAA in the urine, facilitating further research into the role of serotonin in the pathogenesis of canine diseases.
"We have long suspected that some individual dogs and breeds may have higher circulating serotonin than others and that this might predispose them not only to heart disease but also some common diseases such as chronic pancreatitis and kidney disease.
"They would also be more susceptible to serotinergic syndrome when medicated with drugs such as tramadol or trazadone.
"Further research in this area would thus be directly relevant to small animal practitioners."
https://onlinelibrary.wiley.com/doi/10.1111/jsap.70123
The Clinical Research Project grants support the undertaking for small-scale research projects in companion animals, with the ultimate objective of advancing understanding of the causes and/or management of a clinical disorder.
The awards include funding for:
The projects are expected to be completed by 2028.
https://bsava.com/petsavers
The Ageing Canine Toolkit, which was developed from research carried out by the University of Liverpool, aims to help both vets and owners provide the best care for senior and geriatric dogs.
It includes information about common health problems that affect ageing dogs and a colour-coded checklist to help owners know when to seek advice from a veterinary practice and how to guide discussions during consultations.
As part of the partnership, NationWide Laboratories will be distributing the toolkit to its clients, helping raise awareness and make sure that the owners of older dogs know how to look for signs of disease which could enable treatment to be started earlier.
Alison Selby, Fundraising Manager for BSAVA PetSavers said: “We are thrilled to be embarking on this partnership with NationWide Laboratories.
"By supporting the print and distribution costs of this invaluable resource, they will help us reach more pet owners across the UK.
"Working together in partnership, we hope to equip owners with the knowledge and confidence to support their dogs through the ageing process, ultimately improving their quality of life.”
https://bsava.com/petsavers/our-impact/citizen-science-project
The toolkit is part of a major study, the ‘Old Age Pets (OAP) research project’, recently funded by BSAVA PetSavers at the University of Liverpool.
The ACT includes an owner checklist for home triage and a leaflet which explains the more common health problems affecting aged dogs.
There's a practice waiting room poster which includes a QR code to give clients access to a digital version of the leaflet.
The leaflet recommends working through the checklist at least every six months and keeping completed versions for comparison, to monitor dogs as they age.
PetSavers says that some clients may benefit from advice and guidance from RVNs or PCAs on how to complete the checklist for the first time.
BSAVA has also curated a collection of articles, podcasts, lectures and book chapters to support veterinary professionals in caring for senior dogs: http://www.bsavalibrary.com/petsaversact.
Professor Carri Westgarth from the University of Liverpool said: “We conducted this research project kindly funded by BSAVA PetSavers in order to help owners and veterinary professionals provide great care for our loved pets as they age.
“Our investigations uncovered common physical and behavioural signs in dogs that owners observe and for which support from the veterinary practice would be beneficial.
"Our simple evidence-based checklist is designed to engage owners and importantly stimulate efficient discussion with their veterinary team.”
Free digital copies of the leaflet and poster can be downloaded here: http://www.bsavalibrary.com/content/cilgrouppetsaversact, where veterinary professionals can also request free printed copies for their practices.
https://www.bsava.com/petsavers/our-impact/citizen-science-project.
The fellowship provide a grant of up to £35,000 for work in companion animal research to be spent over a maximum of two years.
Applications are open to veterinary nurses who have completed a postgraduate qualification such as a PhD or Masters, and who are within the first four years after starting an academic post (Lecturer, Fellowship or above) and have received no more than £50,000 of funding in competitive external grants to date.
David Killick, Chair of the BSAVA PetSavers Grants Awarding Committee said: “BSAVA PetSavers is delighted to launch the PetSavers Research Fellowship.
"It is well recognised that the journey from completion of a PhD to becoming established as an independent researcher is one of the most challenging times of a researcher career.
“With this new grant BSAVA PetSavers will support exceptional veterinary professionals in the Early Career Researcher phase develop their research ideas by providing £35,000 towards research costs over a two-year period.
"Through this initiative BSAVA PetSavers aims to help these researchers reach their potential and in so doing expand the capacity for companion animal research in the UK.”.
Applications close on 28th February 2022, and a decision will be made by the end of May 2022.
To apply for the Research Fellowship, visit the BSAVA PetSavers website: https://www.petsavers.org.uk/Apply-for-funding/research-fellowship.
BSAVA PetSavers is funding a research project at the University of Liverpool designed to help vets and owners provide the best care for senior and geriatric dogs.
In the first part of the study, veterinary professionals were interviewed about the services currently provided to senior dogs and their owners regarding preventative healthcare, treatment, and advice.
Owners were interviewed about their experiences of living with and accessing veterinary care for senior dogs.
The results of these interviews were then used to develop the online survey which researchers now need vets to take part in, to validate the interview findings in a quantitative way.
Dr Carri Westgarth said: “The veterinary survey focuses on the perceived barriers to care for senior dogs, end-of-life care including quality-of-life, and the potential design of the BSAVA PetSavers guidance tool.
"We would be grateful if any veterinary professional could take a few minutes from their day to help us with this project.”
The survey should take around 20–25 minutes to complete.
Survey participants will also have the opportunity to win an Amazon voucher.
The survey can be accessed here: https://bit.ly/PetsaversOAPVetSurvey.