Speakers include Dr Ian Stroud, founder and veterinary director of Pet People, an independent small animal practice in Richmond, South West London, Jack Peploe, a veterinary IT expert and Certified Ethical Hacker, and Ciaran Milford, ezyVet’s EMEA sales manager, who has worked with every type of veterinary practice, from aspiring independents right through to established universities and corporate groups.
Lance Rice, creative director at ezyVet, who will moderate the webinar, said: “Our speakers are all vastly experienced and ideally positioned to explain what makes a successful launch, as well as the key mistakes and common traps that new owners fall into.
"Ian has a unique understanding of the challenges and opportunities involved with starting a veterinary practice.
"Jack is an expert in helping practices leverage technology to save time, whilst delivering exceptional patient care and bolstering their security posture.
"Ciaran is passionate about helping practices find the right solutions for their needs and business goals."
To register, visit: https://www.ezyvet.com/webinar/starting-a-vet-practice-uk
Although microchipping has been a legal requirement for dogs since April 2016, it is not currently required for cats unless they are travelling under the Pet Travel Scheme.
Cats Protection says microchipping should become a legal requirement for owned cats and is petitioning for change in the law. At the moment, it says, eight out of ten stray cats taken in by its adoption centres in England are not microchipped, making it virtually impossible to trace the owner.
Cats Protection’s Chief Executive, James Yeates, said: "Introducing compulsory microchipping of owned cats would encourage more cat owners to microchip their cats, meaning that lost cats can be identified and returned home rather than handed into rehoming charities as strays.
"It also means that injured cats can be quickly identified by vets and their owners can be informed and involved in their care.
"We’re delighted the Government has shown a commitment towards improving feline welfare and promoting responsible cat ownership in the UK by announcing this call for evidence."
Environment Secretary, Theresa Villiers, said: "Today’s call for evidence on cat microchipping will help the government understand how we can better protect this country’s much-loved cats and kittens. This government is committed to animal welfare and improving the lives of our companion animals."
The call for evidence will last for 12 weeks and respondents are being encouraged to respond as soon as possible. You can take part here.
In short, the old discussion forums have been replaced with a new format where we now invite members to post ONLY questions for the community instead.
Your question can be about anything you like: clinical, practice management, or even something which has nothing to do with work.
Then anyone in the community, which includes fellow veterinary nurses and representatives from industry, can earn points for answering your question.
In due course, points will mean prizes and there'll be rewards for the most helpful community members and the most interesting questions, as voted for by you.
The new VetNurse Community which now exists entirely to help you get good quality, authoritative answers to your questions has a very strict requirement that all participants treat each other with courtesy, respect and good manners.
There will also be a requirement for contributors to share their level of experience in their profile, to give their answers some context.
VetNurse Editor Arlo Guthrie said: "I've struggled for a while about the role of discussion forums in the Facebook era.
"But this, I think, will be a really useful platform which offers something completely different.
"In short, a community exclusively for answering each others' questions; somewhere you can be absolutely certain of a friendly welcome and an authoritative answer.
"If other members of the community don't know the answer to your question, then I personally will go and see whether I can find someone else to help with it"
"Plus I want to make it a bit more fun to help each other, which I think a competitive element, with a leaderboard and rewards will bring"
"The other great thing about asking and answering questions on VetNurse.co.uk is that you will be contributing to a searchable body of knowledge and experience everyone in the profession can benefit from.
"In due course, we'll be upgrading VetNurse.co.uk with all sorts of extra features which will make it easier for you to follow questions, refer back to ones you've had answered, and more."
Meantime, come and try it out.
Post a question for the community today: https://www.vetnurse.co.uk/f
The event will deliver more than 130 hours of CPD, including a programme of five simultaneous live streams each day. Delegates will also have opportunities to network and socialise - with peers, colleagues and experts in chat rooms and breakout sessions, and with industry partners - such as event sponsor Hill’s Pet Nutrition - in the online exhibition hall.
Live content will be delivered via 24 content modules and a library of 100 on-demand webinars will support the 80 hours of live programming. Scientific content will be available on the platform for 30 days and then available to attendees via the BSAVA library.
For the first time nursing, clinical and business topics will be blended into modules from which delegates can select the content they need.
Professor Ian Ramsey, President of the BSAVA, said: "On the clinical side, we’re covering everything from chronic pain and neurology to cardiology and orthopaedics – whatever your interests, there will be something for you."
“Most sessions in the live programme will feature two speakers, each delivering short presentations followed by a live, audience-led conversation. This new approach means delegates can explore the multi-faceted disciplines of the small animal veterinary world and see the clinical challenges from different points of view and, most importantly, join in.
“Pre-recorded webinars support the live programme, enabling delegates to dip in at their leisure. We’ve also swapped traditional lengthy notes or MCQs, with practical resources such as client handouts or flowcharts for delegates to take back to their clinics”.
Congress will also be covering an update on sustainability issues through the module titled, ‘can the profession go green?’ On the practical business front, recruitment and retention will be discussed and keynote speaker Jenny Campbell, a former Dragon on BBC’s Dragon’s Den, will be sharing her experiences as an entrepreneur and business leader.
BSAVA Congress prices start at £99 +VAT. To register, visit www.bsavaevents.com
The Good Veterinary Workplaces Voluntary Code sets out various criteria for what makes a good workplace, based on a new evidence-based BVA policy position.
The code is accompanied by a workbook which veterinary teams can work through together and consider how they might meet a range of criteria. They can also download, sign and display a Voluntary Code poster signalling their commitment to working towards being a good veterinary workplace.
Teams will be asked to assess what they already do well in areas including health and wellbeing, diversity and equality, workload and flexibility, and providing opportunities for personal and career development, as well as identifying areas for improvement and any HR and management processes that need to be put in place to achieve a positive workplace culture.
At the same time, the BVA has also launched its Good Veterinary Workplaces policy position, a paper which offers 64 recommendations for employers and staff on how to offer a fair and rewarding work environment where everyone feels valued.
The BVA says it decided to develop the Good Veterinary Workplaces policy off the back of an extensive body of work looking at workforce issues in the profession, including recruitment and retention challenges, a lack of diversity across the workforce, and general high levels of stress and burn-out in veterinary teams.
The joint BVA/RCVS-led Vet Futures project identified the need to explore the work-related challenges facing vets and take action to create a sustainable and thriving workforce that can maximise its potential.
Gudrun Ravetz, Chair of the Good Workplace Working Group, said: “I’m absolutely delighted to see the launch of our valuable and comprehensive policy, which sets out a vision of the good veterinary workplaces that we should all be striving to create across the profession. This vision has been shaped by valuable contributions from across the veterinary community, and it’s also been really useful to draw on good practice in the wider world of work.
“Each and every one of us deserves to work in a setting where we feel valued, supported and fairly rewarded for the contribution we make, but sadly this isn’t the reality for all veterinary professionals. By setting out the steps that all veterinary workplaces can take to offer a more welcoming and inclusive environment, with measures in place to help them address issues and continue to improve, we hope to see more workplaces where staff can thrive and enjoy a fulfilling career.”
Daniella Dos Santos, BVA Senior Vice President, said: “It’s time for us all to take action to create a culture shift in veterinary workplaces. That means taking positive steps so that diversity and inclusion is championed at all levels, all team members have access to personal and professional development opportunities, and there is recognition that prioritising staff wellbeing is good for businesses.
“In creating the Voluntary Code and workbook, we’ve purposefully made this something that isn’t driven from the top down but is instead something that everyone in the team can feel empowered to feed into and sign up to. This is a golden opportunity for our profession to take ownership of our workplaces, improve conditions, and make sure that we have positive working environments in which we can all take pride.”
Edited by Matthew Rendle and Jo Hinde-Megarity, the manual covers a wide range of species, including cats, dogs, exotic companion and zoo animals.
The book integrates ethics and theory with quantifiable measurement of welfare and evidence-based practical solutions.
It also takes into consideration the welfare of the veterinary team.
The BSAVA says that the book will be relevant to all veterinary professionals and animal carers, as well as those studying animal welfare and behaviour.
Dr Sean Wensley, Chair of the Animal Welfare Working Group, Federation of Veterinarians of Europe, said: "implementing animal welfare policies and activities in a range of settings … can improve patient welfare, client satisfaction, staff morale, staff health and safety, and professional reputation.
"This valuable book will make a significant contribution to helping ensure all of these benefits are realised".
The BSAVA Manual of Practical Veterinary Welfare is available from the BSAVA store: https://bsavaportal.bsava.com/s/store#/store/browse/detail/a1B8d000000icQ9EAI (£90; £58.50 for BSAVA members).
The webinar will take place at 11am and will be repeated at 7.30pm for those who are unable to listen during the day.
Hosted by Zoetis vet Dr Wendy Talbot the session will last for approximately an hour and equates to 8 AMTRA CPD points.
Wendy will explain the current situation and recommended approaches to help slow resistance.
The webinar will conclude with a live Q&A to give everyone the opportunity to discuss any queries, concerns or common questions they hear from their customers with Wendy.
Zoetis Equine Product Manager, Penny McCann said: "Our webinars continue to be very well received.
“This one is particularly important as it explains the important new thinking around the use of anthelmintics in order to address the serious challenge of resistance.
"It’s a must for all those involved with prescribing.”
To book the 11am webinar: https://register.gotowebinar.com/register/6163460189961597967 To book the 7.30pm webinar: https://register.gotowebinar.com/register/6394015684169009164
The Vital Support launch includes a new Feline Renal Multipack to support cats with chronic kidney disease and loss of appetite. The multipack contains four wet pouches with different aromatic profiles to help stimulate decreased appetite and deliver optimum food acceptance and compliance. Multipacks will be available from October 2020.
Royal Canin has also introduced new Early Renal diets to help support the kidneys at early stages of renal insufficiency, and will be discontinuing its Feline VCN Senior Consult Stage 2 diets.
The company is also introducing two new diets for small dogs: Renal Small Dogs to support small breed dogs in the more advanced stages of chronic renal insufficiency, and Mobility C2P+ Small Dogs, formulated to support healthy joint function.
Other changes include a switch to 100% sustainably sourced salmon in its renal wet pouches, and to vegetable sources of glucosamine, instead of shellfish.
For more information, visit: https://vetportal.royalcanin.co.uk, speak to a member of the veterinary pillar team or contact the Nutritional Helpline.
Krka says Arocenia provides fast, broad-spectrum anti-emetic efficacy with a 24-hour duration of action following a single daily dose.
It can be administered intravenously or subcutaneously and is supplied in 20 ml multi-dose vials, allowing up to 40 punctures per vial and a 60-day open vial shelf life.
Renzo Di Florio, Krka’s Technical Veterinary Adviser, commented “Vomiting is one of the most common presenting signs in small animal practice, and maropitant is a medication you’ll find on just about every vet’s dispensary shelf. With Arocenia, we’re adding a cost-effective formulation to the available options.”
https://www.krka.co.uk//products/our-products/animal-health/arocenia-10mgml-solution-for-injection
A few examples of the products in J.A.K Marketing's 'ThinkGreen' portfolio include the Purfect Anaesorber, BAG’EMS biodegradable poop bags, Tick Twister products (made from recycled plastic) and Bamboo stick cotton buds.
The website also gives a snapshot of the sorts of things that J.A.K itself does to reduce its impact on the environment, including the use of environmentally-friendly brown paper and recycled cardboard boxes for packaging. The company has also switched to certified sustainable FSC paper for most of its printed marketing materials (including the master catalogue) and is working with courier companies who have targets in reducing CO2 emissions.
Managing Director, John Holland said: "J.A.K Marketing is committed to the protection and preservation of the world’s ecosystem. By undertaking our productivity and operations responsibly and sustainably, we recognise that reducing the environmental impact of our activities is very important. We will strive to achieve environmental excellence within the veterinary industry and will continue to work closely with our employees and commercial partners to establish and follow the principles of our ThinkGreen policy."
Sales Director, James Johnson said: "With growing interest towards the protection of the environment, we need to make it easier for veterinary practices to identify products where there is a benefit to the environment by simply switching to a like for like ‘greener’ alternative. As part of our long-term strategy, we are dedicated to growing this area of our business, welcoming feedback from the profession of how we can all work together to achieve this."
Those wanting to offer inspiration and feedback can do so on the form at the bottom of the ‘ThinkGreen’ page: www.jakmarketing.co.uk/thinkgreen.
For the project, the company has developed a Brachycephalic Obstructive Airway Syndrome (BOAS) clinical assessment tool which can be used by a vet or nurse in practice to make a diagnosis.
The assessment is a holistic one which includes taking a history of the animal, a full physical examination, an exercise test and an examination of the dog’s nostrils.
The results of the assessment are then discussed with the owner to agree on a course of treatment.
During each consultation, vets and nurses also look to talk sensitively with clients about breeding, buying and owning brachycephalic dog breeds, offering welfare advice on how to manage their dog’s lifestyle, including issues such as keeping their weight low and looking after them in hot weather.
CVS says it hopes this will increase a general level of welfare awareness amongst brachycephalic dog owners.
CVS has also created a collection of resources for its teams, including new clinical frameworks and veterinary guidelines, webinars and a CPD day on the subject.
The company has also created materials to help vets and nurses have what can be challenging discussions with clients, including consultation room posters and practice reception TV videos which showing the physiology of the brachycephalic breed.
CVS says that since launch in July last year, the 25 participating practices have conducted nearly 900 brachycephalic assessments, and it aims to have at least 5% of Pugs, French Bulldogs and Bulldogs undergoing assessment across its small animal division by 2028.
Teleradiology company, VetCT, is calling for companies developing and deploying AI in the field of veterinary diagnostic imaging to impose the highest standards of self-regulation. In an AI position statement released on their website, the company highlights the opportunities and risks associated with the use of AI to interpret diagnostic images.
In the joint statement, company owners Victoria Johnson and Julien Labruyère (pictured right), said: “We strongly welcome the introduction of appropriately developed, tested and implemented AI tools into our profession, to provide solutions to improve resourcing and benefit animal welfare.
“There is a limited pool of veterinary radiologists and an ever-increasing need for expert interpretation of radiographs and more advanced diagnostic imaging modalities.
"This presents a huge opportunity for the development of AI and related technologies to better address demand, save time and potentially improve clinical knowledge and outcomes.
"However, it is important to note that, unlike human radiology, there is no official framework for the regulation, governance and quality control of AI tools in veterinary radiology.
"This means that there should be a very strong onus on companies and individuals to adhere to the highest standards of medical tool development when creating AI solutions.”
“If AI is released into veterinary practice without appropriate oversight or governance there is a significant risk of misleading results, misdiagnosis, and negative impacts on patient welfare.
"This, in turn, may undermine trust in AI and create a culture of hesitancy to adopt new technologies at a time when innovation is much needed to improve access to advanced care.”
The company is advocating for a series of self-regulatory measures to be applied by companies developing AI in order to safeguard both animal welfare and the liability of the veterinary surgeons using these tools in clinical practice.
The full position statement and a list of recommendations can be here: https://www.vet-ct.com/gb/our-services/ai-veterinary-radiology/
The webinar will be presented by veterinary behaviourist, Sarah Heath BVSc PgCertVE DipECAWBM(BM) CCAB FHEA FRCVS, RCVS and EBVS European Specialist in Behavioural Medicine.
It will cover how to take a cat friendly approach to the microchipping appointment to reduce feline stress and make the process easier for both pet owners and veterinary staff.
A consent-based care approach will be discussed, together with the importance of educating cat owners and veterinary professionals on how to handle cats to minimise feline stress.
The webinar will also advise on the use of adjunctive therapies, such as pheromones and nutraceuticals, as well as the strategic use of pre vet visit medication, and will be followed by a Q&A session.
Tammie O’Leary, commercial lead at identi, said: “The introduction of the new cat microchipping legislation will lead to an increased number of feline patients being seen by veterinary practices.
"Our cat microchipping legislation webinar will help provide cat friendly advice for veterinary professionals and will include hints and tips to make cat microchipping appointments as stress free as possible.”
To register for the webinar, email contact@identichip.co.uk or call 0330 9128077.
RCVS Council recommended the increase due to inflationary pressures and increased business costs.
Dr Tshidi Gardiner MRCVS, RCVS Treasurer, said: “We recognise that these are difficult economic times, so Council has endeavoured to limit the fee increase as far as possible; however, in proposing these new fees, Council has had to take account both of increased costs due to inflation, and of additional costs related to ensuring we are fulfilling our regulatory remit to the best of our abilities and meeting our strategic priorities.
“For example, increased costs related to the additional number of veterinary degrees coming on stream, modernising our membership database, our Charter Case Committee, the trial of our private prosecutions protocol against non-vets breaching the Veterinary Surgeons Act, and much more besides.”
“Tilts, Spins, and Tears: Approaches to head tilts in rabbits” will be presented by Dr Madonna Livingstone BVMS MRCVS, who will discuss a range of approaches, diagnostic and treatment options for rabbits presenting with head tilt symptoms.
Madonna has over 20 years experience in veterinary practice, and as Head Vet and Head of Exotics at Ark Veterinary Clinics Ltd, she speaks widely on exotic animal medicine and surgery.
She also delivers clinical exotic lectures and practicals at Glasgow Vet School, holds a diploma in parrot behaviour and is publishing a textbook on rabbits and small exotic mammals this year.
The webinar aims to help veterinary staff to recognise the differential diagnosis list, know how to achieve a diagnosis, or most likely diagnosis within a restricted budget; know the available treatment options; and know how to manage owners’ expectations.
https://horiba.link/head-tilts-in-rabbits
CharcoPet is a ready-to-use oral gel formulated with 50% activated charcoal and marine-derived polysaccharides.
Forte says Charcopet has a high concentration of activated charcoal per ml, which reduces the volume needed and minimises handling stress.
It's supplied in a 2 x 30ml dial-dose syringes, with each syringe suitable for up to 15 kg bodyweight, used at 2 ml/kg bodyweight orally, repeatable every 4–6 hours if clinically required.
Dr Lucy Chadwick MVB ACIM CMktr MRCVS, Global Partnerships Manager & Head of Technical Services at Forte Healthcare said: “CharcoPet represents a major step forward in veterinary care, offering practitioners a fast, precise, and reliable solution when faced with suspected or confirmed cases of toxin or medication ingestion."
https://fortehealthcare.com/product/charcopet/
The training will take place in locations across BSAVA’s regional network in the UK, and is open to large, small, and equine veterinary teams.
The sessions will cover the complexity of abuse and the impact of domestic abuse on children, how to recognise abuse/non-accidental injury in animals, how to document information and what to do when dealing with disclosure from a human victim of abuse.
They will also give guidance on setting up a practice protocol and identifying a practice links adviser who will assist those involved in the veterinary team to manage suspected cases of abuse.
Invited guests will include representatives from human and veterinary health, welfare bodies and policy makers.
Vicki Betton, Vice-Chair of The Links Group said: “We’re thrilled to be rolling out our programme of in-person training days with BSAVA.
"Abuse of any vulnerable member of the family, human or animal, is a difficult subject for many to even consider, but with reported cases of domestic abuse reaching an all-time high during the pandemic, its essential that teams are aware of the issue and have a practice protocol in place for if they feel something isn’t quite right with a case.
“We’re looking forward to exploring the most effective ways veterinary teams can recognise and act on suspected cases of non-accidental injury or disclosures of domestic or child abuse.”
The training days are free for BSAVA members and £50 (inc VAT) for non members.
So far, dates have been confirmed for Nottingham on 18th April and Exeter on the 29th June. Others are planned for the Metropolitan, Southern, Wales and North West regions.
To book your place, visit: https://www.bsava.com/education/cpd/regional-cpd
Visitors will be given a behind-the-scenes look and have the opportunity to chat with Specialist surgeons Former Member and Chris Jordan.
Andy said: “We have had a fantastic first six months, and to say thank you to those who have referred cases to us, and to show off our facilities to those who haven’t seen the clinic, we are thrilled to be holding an open evening.
"I’m looking forward to providing tours of the clinic and having a chance to talk to vets about our services and how we can help.”
All veterinary professionals and their families, and pet owners are welcome.
The clinic is situated just off the M3 and 30 minutes from the M25, in the village of Upton Grey, near Basingstoke.
To register your interest and book a place at the open day please contact Marie at Marie@mooresortho.com or 01256 632100.
The referral centre has invested in a new heart and lung machine, and an oxygen cage, and is expected to take its first patients in the autumn.
The service will be established and led by head of cardiac surgery Poppy Bristow (pictured right) and head of cardiology Anne Kurosawa, who have already performed this kind of surgery on more than 100 dogs to date.
DWR is also setting up its own blood transfusion service to collect blood from staff and clients’ pets to support the service.
The blood collected will also be used to support the practice’s emergency and critical care service and its planned dialysis programme.
Poppy said: “There are hardly any other centres in the world offering this type of surgery, especially with this level of expertise that comes from the collective team we have gathered at DWR.
“Mitral valve disease is the most common heart condition in dogs and sadly, many dogs die every year as there are very few options for treatment. To be able to offer surgery to more dogs and their owners is really exciting.
“DWR is the perfect environment for this pioneering programme, due to the state-of-the-art equipment and depth of expertise on hand to support this life-saving initiative.”
Rob Foale, clinical director at Dick White Referrals, added: “It’s a hugely significant step for us to be launching this service, drawing on Poppy’s expertise in this field.
“We’re also starting our own blood transfusion service to complement the launch, as the pandemic has led to a huge drop in pet blood donations.
“Any excess blood we collect will be donated to the national Pet Blood Bank charity, which supplies blood to veterinary practices across the UK and does a fantastic job.”
For more information, visit www.dickwhitereferrals.com.
The training will be delivered by the referral team and is open to all vet nurses, trainee vet nurses and animal care assistants, with content for all experience levels.
Topics on the day include:
Eleri Counsell, Nursing Manager at Langford, said: “The Congress has gone from strength to strength since it was launched in 2022.
"Our aim has been to showcase our outstanding nursing team here at the Small Animal Referral Hospital and continue to support our local referring practices and the wider veterinary nursing community by sharing our expertise.
"The nurses have really been the driving force for this Congress and their passion when talking about their areas is inspiring.”
Tickets cost: £150
https://www.eventbrite.co.uk/e/vet-nurse-congress-2024-tickets-793211144887
The new guidelines are freely available in the Journal of Feline Medicine and Surgery (JFMS), along with new consensus guidelines for vets and a guide for caregivers.
Samantha Taylor, iCatCare Veterinary Specialist Consultant and co-author and panel chair for the guidelines said: “There have been significant developments in the treatment of feline diabetes mellitus since the publication of the 2015 ISFM diabetes guidelines.
"Experts in the disease from the USA, Netherlands, UK, Australia and Italy have collaborated on a much-needed update and the resulting 2025 iCatCare consensus guidelines are an essential information resource for vets diagnosing and treating diabetes mellitus in cats.”
https://internationalcatcare.cmail20.com/t/i-l-znwll-tykyklax-k/
The expansion has increased the hospital's footprint by 30%, adding three new operating theatres, six new consult rooms and new feline facilities, including a cat-only waiting room, consult room and treatment area.
Hospital owner, IVC Evidensia said the expansion has been driven in part by the pet ownership boom of the last few years and increased demand for the hospital’s services.
To meet the demand, Vale has expanded its office space, adding desk space for a further 25 vets.
There are also new ultrasound and cardiology rooms, a new dental suite and enlarged prep and recovery areas.
The existing kennel area has doubled in size with the addition of nine new walk-in kennels, a bespoke isolation ward and secure outdoor runs.
Richard Artingstall, clinical director at Vale Referrals, said: “We’ve been working on this expansion for a long time and it’s incredible to see it complete.
"Our new and improved facilities mean we can give even more pets across the Southwest the gold standard treatment that they deserve and support our colleagues from neighbouring vet practices with extensive referral services.
"The feedback from pets and owners so far has been very rewarding to hear.”
The feedback from pets?
Really?
VetSurgeon.org contacted recent patient Dougal McDoggins for comment.
He said: "Woof."
www.valereferrals.co.uk.
The Association says it has produced the leaflet after seeing an increasing number of dogs diagnosed with clinical or subclinical infection, along with reports of its zoonotic impact.
The document outlines the most important considerations concerning B. canis including transmission, diagnosis, management, public health implications and legislative requirements.
It takes into consideration information available from relevant Government Departments.
BSAVA says the document is by no means exhaustive but is intended to provide useful information and signpost to further resources.
www.bsavalibrary.com/brucella_canis
Photo: Walker16/Wikipedia. CC BY-SA 4.0.
The practice is now accepting dental referrals, including for dental, oral and maxillofacial surgery.
Hannah said: “I am proud to join the Fitzpatrick Referrals team to extend their referral offering to include this very important aspect of small animal veterinary treatment.
"Working alongside a world-class team with state-of-the-art facilities is a fantastic opportunity.”
https://www.fitzpatrickreferrals.co.uk/services/dentistry/
APPA is an oral, patented, fixed-dose combination of two synthetic secondary metabolites of plant origin, apocynin and paenol.
Under the terms of the agreement, AKL’s unnamed partner will fund a study in dogs with naturally occurring OA. The study will compare the efficacy and efficacy duration of APPA with the current standard of care for treating canine OA: non-steroidal anti-inflammatory drugs.
David Miles, AKLRD CEO, said: “Just like humans, millions of dogs suffer intolerable pain and disability because of OA and the current treatments just aren’t as effective or as well tolerated as they need to be. We already know from previous canine studies that APPA reduces pain and has an excellent tolerability profile but this exciting new partnership will allow us to go one stage further and assess sustainability of response.”
The randomised study will assess pain and duration of response as the primary endpoint. Secondary endpoint assessment will include adverse events, quality of life, pharmacokinetics analysis and biomarkers that may enable potential identification of factors predictive of response at treatment onset, or that correlate with response magnitude.
Two separate studies on dogs have already been carried out by researchers at the University of Vienna. The first, an 11-week cross-over study of 32 canines diagnosed with established, naturally occurring OA, showed that APPA provides significant symptom relief in clinical canine OA1.
A follow-up, five-week study of 60 dogs with OA compared APPA to the standard of care drug, meloxicam. It concluded that daily oral administration of APPA was effective as a stand-alone alternative to NSAIDs in dogs with naturally occurring OA. Significant benefits were also seen for APPA over meloxicam in orthopaedic examination as well as in lameness and function scores2.
The results will inform the pivotal clinical trial design and AKL says its working assumption is that a 26-week field study would complete the regulatory requirements for commercialisation.
If the study and future testing is successful, AKL estimates that APPA would be well placed to capture a significant share of the global canine OA market, which is estimated to be worth $3billion by 20283.
References