The stem cells were created as part of a study into feline hypertrophic cardiomyopathy (HCM), which the RVC carried out in association with the Animal Health Trust (AHT), The Beryl Evetts and Robert Luff Animal Welfare Trust (BERLAWT), The Winn Feline Foundation and Boehringer Ingelheim.
The RVC says HCM affects about 15% of the feline population in the UK; translating to over 1 million cats. It is caused by genetic mutations which affect the heart muscle cells.
To date, there are no treatments proven to stop or reverse it, leading to a very poor prognosis for affected cats.
This is partly because a major issue with studying heart diseases at a cellular level is that heart muscle cells do not survive in a laboratory environment. When studying human heart cells, this has been overcome by turning ordinary skin cells into pluripotent stem cells (cells able to turn into any tissue in the body).
These are termed 'induced pluripotent stem cells', or iPSCs. It is then possible to generate heart muscle cells to study from these iPSCs.
The research, carried out by Dr Luke Dutton under the supervision of Professor David Connolly, Dr Jayesh Dudhia and Dr Debbie Guest, as part of his PhD at the RVC in collaboration with AHT, has now identified the conditions required to create iPSCs from domestic cat cells.
While creating iPSCs has been done before in wild cats, the RVC believes that Dr Dutton’s breakthrough in creating iPSCs from domestic cat cells is a world first. It sets the scene for further research into how to turn these iPSCs into heart cells and then, once successful, testing drug therapies that could improve outcomes for cats with HCM.
The researchers say that the translational benefits of this project are potentially very significant, as around 1 in 500 people in the UK have HCM, and the condition manifests in humans in the same way.
If the therapies that researchers test on feline heart cells turn out to be effective, this sets the stage for testing these treatments on humans.
Dr Dutton, author of the study, said: "This is an incredibly exciting project, which is only made possible by the generous funding of the BERLAWT, Boehringer Ingelheim and The Winn Feline Foundation.
"Not only is this study the first reported generation of iPSCs from domestic cats, but these cells can now be used in a novel disease model. This will allow us to study the disease processes present in these cats in ways that have not been possible with the ultimate goal of identifying new therapeutic agents that may slow or even stop the disease process. We would then hope to translate these agents into the feline clinic."
Dr Debbie Guest, Head of Stem Cell Research at the Animal Health Trust, said: "This is the first report on the successful generation of domestic cat iPSCs. These cells not only bring hope to cats suffering from HCM, but allow us to develop new tools to study conditions affecting other tissue types in the future."
The decision was made after Council heard increasing reports that practices have not been keeping records of POM-V parasiticide prescriptions within patient records as has always been required by the VMD.
This created a bit of a problem when the new 'under care' guidance came into force at the start of this month, which requires that veterinary surgeons must perform a physical examination as part of their initial clinical assessment of an animal before prescribing POM-V anti-parasitics.
Failing a record of an existing prescription, that would have meant re-examining large numbers of animals at a time when resources in the profession are already stretched.
RCVS President, Sue Paterson, said: “While it has been both surprising and disappointing to learn of such widespread non-compliance with legislation that has been in place for many years, Council decided to postpone the implementation of this one aspect of our new under care guidance to allow practices additional time to bring their prescribing protocols into line."
The delayed implementation date of 12 January 2024 relates only to the prescription of POM-V anti-parasitics.
The rest of the new under care guidance remains in effect from 1 September 2023
Bordetella bronchiseptica is a clinically significant pathogen for canine infectious respiratory disease (CIRD), otherwise known as kennel cough, with 78.7% of dogs with acute respiratory signs testing positive for the bacteria1.
In the same study, 45.6% of clinically healthy dogs also tested positive for Bordetella bronchiseptica, illustrating that clinically healthy dogs can carry respiratory pathogens and could act as sources of infection for susceptible dogs1.
Administered via subcutaneous injection, Canigen Bb is an inactivated subunit vaccine which offers vets a new option when intra-nasal vaccination with a live aerosolised vaccine is not possible or preferred, for example when the dog is in contact with known immunocompromised individuals.
Licensed for use in dogs from 6 weeks of age, Canigen Bb extends protection against Bordetella bronchiseptica in dogs vaccinated with Canigen KC in the last 12 months for a further year with a single dose.
Canigen Bb is presented as a ready-to-use formula in a 10ml multi-dose bottle and can be stored at room temperature (2°C - 25°C) for up to 4 weeks once broached.
It can be administered concurrently (at the same time but separate injections) with Canigen DHP, Canigen DHPPi, Canigen Pi & Canigen Lepto 4.
Andrew Connolly, Marketing Director at Virbac, said: ‘It is our hope that Canigen Bb will increase the overall uptake of Bordetella bronchiseptica vaccination to provide increased protection against this widely prevalent and clinically significant disease’.
Reference
Reporting into Chief Veterinary Officer Paul Higgs, Tara will focus on the development of the role of veterinary nurses in CVS.
The role of CVNO at CVS was previously held for a two year term.
CVS says this appointment of a permanent CVNO is to ensure greater continuity in veterinary nurse representation during an important phase of the company's development.
Paul said: “I am excited to welcome Tara into this role to ensure we continue to champion the role of veterinary nurses in CVS and in the profession as a whole.
“Those that know Tara will recognise she is passionate about the role of RVNs and is well positioned to support and influence the importance of the work they do across our company.”
“I am excited to be working alongside Tara as we engage with our teams and continue to foster the right environment to empower nurses and deliver fantastic clinical care in our practices.”
Tara began veterinary work in Norfolk 23 years ago and she joined CVS Group in 2008 as Head Nurse at a practice in Oxford.
She was one of the first CVS Clinical Directors to come from a nursing background and has since moved on to become Regional Director of practices in Norfolk and Suffolk.
The first is that the College will allow veterinary surgeons and nurses to carry over some of the CPD hours they have accrued in 2019 into 2020, to smoothen the transition to an annual hourly requirement.
Vets will be allowed to carry over 25 hours and VNs 10 hours of accumulated CPD from 2019 through to 2020.
This will apply once, in 2020 only, and is only applicable to vets and VNs who have been CPD-compliant from 2017 to 2019 and have a surplus number of hours to carry over.
Secondly, the College is going to allow vets and VNs to take a six-month 'CPD pause' for planned periods away from work, such as parental leave, and exceptional circumstances, such as serious ill health or unforeseen changes to family responsibilities, without the need to make up the hours when they return to work. This will reduce the burden on vets and VNs returning to work after a break.
RCVS Director of Education, Dr Linda Prescott-Clements said: "We hope that these changes to the CPD policy will support vets and VNs to make the transition to an annual hourly requirement.
"We received a sample of feedback from some members of the veterinary professions regarding the move to annual hourly CPD requirements and these additions have been introduced support members during this transition and to mitigate some of the concerns raised."
For more information about the CPD requirement for both vets and vet nurses, what activities might count as CPD, how to record your CPD and a series of frequently asked questions about CPD please visit our dedicated page: www.rcvs.org.uk/cpd.
The two-day ‘Save A Life Today’ (SALT) courses are being run in partnership with the Reassessment Campaign on Veterinary Resuscitation (RECOVER).
Vets and nurses are encouraged to attend together, as well as individually, so that they can go back to practice and share their learning as a team.
On day one, delegates will cover the practical aspects of resuscitation.
The second day will be focused on effective leadership during and after CPR and the critical care of patients that survive CPR, with an emphasis on techniques used in general practice.
The courses will be led by Emily Thomas BA VetMB FHEA DACVECC DECVECC MRCVS Specialist in Emergency and Critical Care at Dick White Referrals, supported by Kathryn Latimer DipAVN DipHE CVN CertEd CertVN (ECC) RVN, Head of Nursing Services at North West Veterinary Specialists in Cheshire.
Charlotte French (pictured right), Operational Head for Improve International in the UK, said: “When CPR is attempted, it can be stressful and distressing for those involved.
"It’s also a situation in which clear thinking and teamwork can save lives.
"Through our partnership with RECOVER, we hope to increase the competence and confidence of veterinary staff globally in conducting CPR and to facilitate the building of team-working which will radiate into other areas of day-to-day practice."
Emily Thomas said: “CPR training for vets and nurses has traditionally focused on individual tasks such as chest compressions.
"However, we’re now realising that human factors such as organisation, teamwork, and leadership are equally integral to success.
"This is an area of particular interest for me, and I’m hoping to bring some simple, evidence- based ideas to this course to help people improve these non-clinical aspects in their own practices.”
The course is comprised of an online training module, followed by a face-to-face course which together account for 20.5 hours of CPD. Successful delegates will become Basic and Advanced Life Support RECOVER Rescuer Certified.
There are a record 14 candidates standing for the RCVS Veterinary Nurses (VN) Council this year, none of whom are currently members of VN Council. They are:
As current VN Council member Susan Howarth RVN was the only candidate to come forward before the original candidate deadline of 31 January 2021, she has automatically been re-elected to VN Council for a further three-year term. This means that there is only one remaining elected place on VN Council.
Emails containing links to the secure election voting websites which are unique to each member of the electorate, were sent on 17 March 2021 by Civica Election Services (CES) (formerly Electoral Reform Services) which runs the election on behalf of the College.
All votes must be cast online by 5pm on Friday 23 April 2021. The small number of veterinary nurses for whom the RCVS does not hold email addresses have been sent letters in the post containing instructions on how they can vote online, including contact details for CES to provide further advice.
The biographies and statements for each candidate can be found at: www.rcvs.org.uk/vnvote21
VN Council candidates have also been asked to record a video highlighting the two issues they feel are most important for the profession. They will be published on the College website in due course.
DogStem has been shown to be effective, reducing pain and lameness and improving mobility and quality of life for three months to over twelve months following a single injection1,2.
In a prospective, randomised, double-blinded, placebo-controlled trial of DogStem, results showed that2:
TVM highlights how DogStem simplifies the process and reduces the cost of using stem cell therapy in practice because unlike previous therapies, it does not require require a surgical harvesting procedure to be carried out under general anaesthetic.
Helen Harrison, DogStem Technical Vet and Product Manager said: "Osteoarthritis is one of the most common diseases seen in veterinary practices and is challenging to manage.
"Conventional medical treatments typically address the symptoms rather than the underlying pathological processes.
"At the same time, local treatment options that slow progression of osteoarthritis have been limited and surgical interventions aren’t always possible or may be unrewarding.
"We’re delighted to be able to offer vets DogStem®, a stem cell product with a strong evidence base across numerous mobility and quality of life parameters.’
DogStem can be ordered from NVS, or direct from: www.dogstem.co.uk
References
The study, which was led by the College's VetCompass programme, found that British bulldog ownership has increased from 0.35% of all puppies born in 2009 to 0.60% in 2013.
At the same time, the study found that British bulldogs suffer more than other breeds from a number of conditions associated with their aesthetic characteristics, including: skin fold dermatitis (7.8%), prolapsed gland of the third eyelid or 'cherry eye' (6.8%), interdigital cysts (3.7%), entropion or inward turning of the eyelid (3.6%), and corneal ulceration (3.1%).
Worse still, only 3.5% of the 1,621 British bulldogs analysed in the study were diagnosed with brachycephalic obstructive airway syndrome (BOAS), despite an earlier study reporting that 84.8% of tested Bulldogs are affected by BOAS to some extent, with 44.0% exhibiting clinically relevant disease2.
This, say the researchers, suggests owners consider breathing problems such as snoring as normal and are not therefore taking their dogs for needed check-ups.
Other findings included:
12.7% of British bulldogs suffer from ear infections, 8.8% from skin infections and 8.7% from obesity
Males are more likely than females to develop skin infection, interdigital cysts, atopic dermatitis and aggression, whereas females are more likely to develop dental disease and obesity.
The average adult bodyweight for a British bulldog is 26kg.
The average lifespan of bulldogs is 7.2 years.
The most common causes of death are heart disease (11.8%), cancer (10.9%) and brain disorder (9.1%).
The RVC says that the results of the study will support initiatives by the Kennel Club and the UK Bulldog Breed Club to improve breeding and also help owners and vets prioritise tackling the leading issues British bulldogs face.
Dr Dan O’Neill, VetCompass epidemiologist at the RVC and Chairman of the Brachycephalic Working Group, said: "The UK has seen unprecedented increases in the popularity of certain short-faced breeds over the past decade. This has led to a series of well-documented welfare issues relating to how these dogs are bred and sold for the UK pet-owning market, high levels of dumping of unwanted dogs into the UK charities and health problems that are intrinsically linked to the extreme body shape of these dogs.
"This new study gives firm evidence for the first time on the true levels of popularity and also of disease diagnosed in the wider population of bulldogs in the UK. This information can help to move the conversation on welfare from 'what are the issues' to 'how do we deal with these issues'. Reliable evidence is pivotal to good decision-making."
Dr Rowena Packer, BBSRC Research Fellow at RVC, said: "The bulldog is an iconic breed but concerns over the health problems allegedly facing these popular dogs have mounted in the past decade. It is extremely valuable to have solid data on the health problems facing this breed, confirming a number of inherent breed predispositions that need to be tackled.
This data supports current initiatives encouraging breed reform, particularly regarding health problems inherently related to their looks, and the need for selection for healthier body shapes. For example, skin fold dermatitis was common in bulldogs and is associated with the desired wrinkled face in this breed – this calls into question the justification of this and other such breed traits that put dogs at risk of potentially avoidable disease."
Steve Dean, Chairman of the Kennel Club Charitable Trust said: "The Kennel Club has put into place a number of crucial measures over the years to monitor, protect and improve bulldog health and to provide the many responsible breeders with the tools they need to do the same, but this paper highlights there is still work to be done."
The study is published open access in PLOS ONE.
References:
Preoperative fasting to reduce the likelihood of gastroesophageal reflux, regurgitation, emesis and aspiration of gastric contents during anaesthesia is routine, but research on the topic is currently thin on the ground.
The survey aims to obtain information on current preoperative fasting recommendations and protocols in dogs and cats which will enable the expansion of knowledge on common practice. Kat (pictured right) said: "It will also allow me to compare current practice to the literature to examine the use of evidence-based practice. It may also highlight areas requiring improvement in small animal practice to ensure patient health and welfare."
The anonymous questionnaire is aimed at a number of veterinary staff including registered veterinary nurses, veterinary surgeons, students, animal care assistants, veterinary care assistants and reception/administration staff as all are involved in providing advice and instructions to clients on this topic.
Kat plans to share significant findings with the profession in due course.
To take part in the survey, visit: https://harper-adams.onlinesurveys.ac.uk/preoperative-fasting-duration-questionnaire
The survey will close on Friday 14th August 2020 at 5:00pm.
Please share this story with colleagues!
The new guidance will remove the absolute requirement for veterinary surgeons to perform a physical examination before prescribing POM medicines, making it instead a matter for professional judgement.
However, the proposed new guidance also imposes a requirement for veterinary surgeons who do NOT physically examine the animal prior to prescribing to provide a 24/7 follow-up service which includes a physical examination.
Furthermore, the new guidance will state that: "Where the veterinary surgeon is not able to provide this service [the physical exam] themselves, they should arrange for another veterinary service provider to do so. This arrangement should be made before veterinary services are offered and confirmed in writing as part of the conditions of service agreed by the client."
This requirement to provide a physical 24/7 follow-up would appear to safeguard animal welfare and protect against the risk of online-only businesses (in the UK or abroad) with lower overheads cherry-picking the job of prescribing medicines.
It should also protect against veterinary surgeons feeling pressured to prescribe inappropriately, because the new, stricter requirements will make it easier for them to decline to do so.
However, the BVA doesn't agree with the new proposals. It feels that remote prescribing should be delivered under the auspices of a Veterinary Client-Patient-Relationship (VCPR), which, according to the American Veterinary Medical Association, requires a physical examination.
BVA President Malcolm Morley, said: “The changes to ‘under care’ guidance are a watershed moment, so it’s positive to see that they have evolved in response to feedback from the profession. New technology presents exciting opportunities to enhance existing veterinary services and has benefits for practices as well as clients and their animals.
"However, BVA has been very clear that we believe remote prescribing can only be safely delivered where a vet-client-patient relationship has been established.
"This is an internationally recognised concept, and we are disappointed that the RCVS has decided not to embrace it.
“Having voted to implement these changes, it is incumbent upon the RCVS and the profession to scrutinise how they play out.
"At BVA we plan to develop advice and resources to support our members and help them comply with the new guidance and realise any benefits of remote veterinary service provision.’
“It is now vital that a timeframe for a review is quickly put in place, so any negative impacts on animal welfare or the sustainability of veterinary services can be dealt with swiftly.”
Council voted by a majority of 20 to 3 in favour of the changes, which it then decided should come into force between 1st June and 23rd December 2023, subject to a review at the next meeting.
Discuss the propose changes here
Propomitor can be used for the induction and maintenance of general anaesthesia for procedures lasting up to five minutes by the administration of incremental doses or as a constant rate infusion (CRI).
It can also be used for the induction of general anaesthesia where maintenance is provided by the inhalation of anaesthetic agents.
Animalcare Product Manager Kai Crawshaw said: "Propofol is the ‘go to’ solution for short-acting anaesthesia in many practices so we are delighted to add Propomitor, our new affordable propofol solution, to our range. It complements our already extensive anaesthetic toolkit, which offers options for analgesia, sedation, gaseous anaesthesia and recovery."
Propomitor is available in boxes of 5 x 20 ml bottles.
For more information, contact your Animalcare Territory Manager or Animalcare’s head office on 01904 487687.
The plan covers mortgage or rent payments of up to £2000 per month for up to a year if you are unable to work because of illness or injury.
In addition, policyholders, their partners and children under the age of 18 are given access to a 24/7 GP service, available via video or phone consultations.
VetYou says there no health or financial questionnaires involved, and whilst permanent conditions and those present within the last two years are not covered, Home Protection will start to cover pre-existing conditions when you have been symptom, medication and treatment free for two years.
There are 12 types of higher risk sports and hobbies Home Protector wont cover cover and Home Protector can’t cover semi-professional or professional sports.
Matthew Dobbs, one of the founders of VetYou (pictured), said: “As practising vets, we know the pain of trying to cover rent and mortgage payments when we are unable to work.
"But as busy professionals we often don’t find the time to get the cover we need.
"So we worked with Future Proof to bring this exclusive product to the profession."
https://vetyou.co.uk/home-mortgage/home-protector
The awards, which which celebrate initiatives that advance the quality of veterinary care and demonstrate a commitment to using an evidence-based approach, will be open for applications until 13th January 2023.
The two new award categories are Antimicrobial Stewardship and Canine Cruciate Outcomes.
The Canine Cruciate Outcome Awards are to recognise and celebrate individuals and teams who are using Quality Improvement initiatives alongside RCVS Knowledge’s Canine Cruciate Registry (CCR) to monitor and improve their canine cruciate surgery outcomes.
Applications are invited by surgeons and teams who are using the CCR.
The Antimicrobial Stewardship Awards, which are divided into farm animal, equine, and companion animal categories, aim to showcase practical examples where individuals and teams are improving responsible antimicrobial prescribing.
In addition, the charity is looking for entries for its existing awards for students and those who have implemented Quality Improvement (QI) techniques.
The Veterinary Evidence Student Awards enables students from around the world to enhance their academic and research skills by writing a Knowledge Summary and submitting it for publication to Veterinary Evidence, RCVS Knowledge's open access, peer-reviewed journal.
The Quality Improvement Awards showcase the implementation of Quality Improvement techniques which drive improvement within the professions.
www.rcvsknowledge.org/awards
Alice and Mariella, who co-authored the book Cracking the Menopause, met with MPs earlier this month to present the goals of their campaign: education for all on the menopause, an end to scaremongering, prescribing women with the correct medication and making HRT affordable and accessible to all.
Vets Now says 88% of its 1800 employees are women, 28% of whom are aged over 40, when they could be perimenopausal, menopausal or postmenopausal.
The company's new app offers its employees video consultations with health experts, health and fitness programmes, and support with mental health and nutrition.
Vet's Now says it's the starting point for a wider menopause support plan being launched later in the year which will include steps to help manage mental wellbeing at work, menopause support hubs and encouraging a culture which talks honestly about menopause.
Laura Black, Head of Health, Safety and Wellbeing, said: “Women over 50 are the fastest growing demographic in the workplace and sadly it’s estimated that almost 900,000 women in the UK have quit their jobs due to the menopause.
“We are committed to creating an understanding workplace for employees going through the perimenopause and menopause and want to make sure they feel supported by us at all times.
“We've launched Peppy to help our colleagues take control of their health and get the answers they need from experts, anytime, anywhere.
"The app is free to access for all employees and their partners.
“We’ve been working hard on formulating a menopause support package for staff over the past couple of years and we’re really proud that we’re one of the first major veterinary businesses to make this step change.
"We’d encourage other businesses in the sector to look at similar plans for their colleagues.”
While the drive to launch Peppy was initially to support the Vets Now Menopause policy, it also provides support for fertility, pregnancy, early parenthood and men’s health.
For more information on Peppy visit www.peppy.health.
The peer-reviewed manual, available for download from the VMG website, has been designed to be relevant for any veterinary business and has been developed following a review of the contemporary academic and business literature, with input from the VMG Board of Directors.
The Business Re-emergence Manual guides readers through three main areas that need to be considered as they emerge from lockdown:
VMG President Richard (Rich) Casey said: “Depending on the circumstances in which businesses entered the pandemic, it’s likely that they will be affected by a range of people, planet and profit-related issues as lockdown restrictions start to ease.
"Our Business Re-emergence Manual encourages veterinary leaders to take a step back and reflect on how their business was performing before the pandemic as a first step before starting to make plans for their future operations. Investing in this ‘thinking time’ now will enable them to ramp up more quickly and more effectively when the time is right. It is an evidence-based and highly practical tool which all veterinary businesses can work through and we hope they will find it useful as they start to plan for a successful future.”
To support veterinary practices and staff affected by the COVID-19 emergency, the Veterinary Management Group (VMG) is pausing subscription renewals for all of its existing members for three months, in effect, giving them three months’ free membership, including access to resources such as the Business Re-emergence Manual. It is also offering everyone in the sector the opportunity to join the association for three months, also free of charge.
The researchers say that the findings pave the way to generating new and important information about the development chronic kidney disease (CKD) and hypertension (HTN) in cats.
The RVC says that about 30% of cats aged 10 years or older have CKD, which equates to approximately 600,000 in the UK.
Of these, about 40% will also have hypertension.
The research team was led by principal investigator at the RVC, Dr Rosanne Jepson, alongside joint first author from Queen Mary University of London, Dr Helen Warren, and Professor Patricia Munroe.
The team examined the archives of 1,022 domestic cats seen at both the RVC’s Beaumont Sainsbury Animal Hospital and Bow PDSA Pet Hospital since 1992, looking for genetic associations with CKD and HTN using a genome-wide association study (GWAS) approach.
The GWAS approach used a special feline array to characterise over 63,000 genetic differences across the feline genome.
The team examined the influence of different genes on disease traits which may point to new ways of treatment as the pathways and proteins controlled by these genes can indicate novel mechanisms for disease development.
Researchers say that this study method has historically been used for rarer and breed-specific conditions where single genetic mutations might be occurring.
However, the findings show it could now be used to generate new information about common and complex diseases which are likely to be the result of genetic, lifestyle and environmental risks.
Rosanne Jepson, Principal Author of the paper and Associate Professor in Small Animal Internal Medicine at the RVC, said: “This was an exciting opportunity to explore potential genetic influences on the development of chronic kidney disease and systemic hypertension in cats, collaborating with key opinion leaders who work and have published extensively in this field in human medicine.
“These conditions are complex - meaning that there are many factors relating to genetics, lifestyle and environment that cumulatively determine whether an individual may develop either CKD or hypertension in their lifetime.
“This study has shown us, as proof of concept, that large scale genomic studies will be important for understanding the pathogenesis of such complex disease conditions and may help to identify novel pathways as targets for diagnosis and management in the future.”
The charity says that although histiocytic sarcoma is rare, it is an aggressive form of cancer which Flatcoated Retrievers are particularly susceptible to.
According to the AHT, almost half of all affected Flat-coated Retrievers will have a tumour in multiple locations in the body at the time of diagnosis. The outlook for these dogs is very poor and, in most cases, means they receive a terminal diagnosis.
The new research revolves around microRNAs, abnormal levels of which are often found in tumours. In addition, different microRNAs are involved in different cancers. These cancer-specific microRNA signatures can be found within the blood of cancer patients, meaning that a tumour could potentially be diagnosed with a blood test.
To start with, the researchers say they plan to confirm if there is a specific microRNA signature that is unique to histiocytic sarcomas amongst tumours and normal tissue samples from Flatcoated Retrievers. If a signature is identified, the project will investigate if measuring the levels of these microRNAs within a Flatcoated Retriever tissue sample can be used to accurately identify a histiocytic sarcoma. If it can, additional funding will be sought for more research to identify if the microRNA signature is also detectable in the blood of affected dogs, and thence to develop a blood test.
If it comes off, this would mean that a blood sample from a Flatcoated Retriever that was lame, or was showing non-specific clinical signs of the disease such as depression, lethargy, appetite or weight loss, could be tested for the presence of the histiocytic sarcoma-associated microRNAs.
A dog with a positive test result could then have an early MRI scan and histopathology done to confirm the diagnosis, hopefully at a stage where treatment would be more successful.
Dr Anna Hollis, cancer researcher at the Animal Health Trust, said: "I have Flatcoated Retrievers and have lost one of them to histiocytic sarcoma - it is absolutely devastating. This research could make a significant difference, and that is a huge personal motivation for me. Histiocytic sarcoma is a particularly tricky cancer to diagnose, because the tumours are frequently located deep within or between the muscles of the upper limbs - underneath the shoulder is a common location.
"Often lame dogs are rested and given pain relief before imaging is sought. Delayed diagnosis is a potential problem with histiocytic sarcoma given its aggressive nature and ability to spread rapidly to other locations within the body. If we could identify affected dogs at an earlier stage, this may allow more successful treatment of the disease."
The research project has been funded by the Flatcoated Retriever Society (FCRS) and the FCRS Rescue, Rehousing and Welfare Scheme. The Flatcoated Retriever Breed Health Co-ordinator, Liz Branscombe, said "Sadly, there is a high incidence of this aggressive form of cancer in our beautiful breed. Early detection of the disease is key in optimising cancer treatment and prolonging survival time so the prospect of a diagnostic blood test for use in the future is exciting.'
Photo: Liz Branscombe, Dr Mike Starkey and Dr Anna Hollis of AHT and Brian Jones of FCRS Rescue, Rehousing and Welfare.
The new series comprises six online discussions taking place over the course of the spring, covering everything from diversity to creativity to identity.
The upcoming programme of events is as follows:
Tuesday 1st March 2022 7pm to 8pm: Celebrating diversity Chaired by Gurpreet Gill, RCVS Leadership & Inclusion Manager. Panel members Lacey Pitcher RVN, Dr Olivia Anderson-Nathan MRCVS and Samantha Payne RVN will be talking about what celebrating diversity means to people, exploring how this links to mental health, and sharing their thoughts on why – and how – the professions should be working towards greater inclusivity, both in and out of the workplace.
Monday 21st March 2022 7pm to 8pm: The joy of creativityThis discussion will look at why creativity is so important for people’s lives and how it can be used to support mental health and wellbeing with a panel comprising Dr Silvia Janksa MRCVS and Olivia Oginska MRCVS.
Tuesday 5th April 2022 7pm to 8pm: Overcoming self-doubt and stressing outThis discussion will consider the main causes of stress in the veterinary workforce and how this may have shifted throughout the pandemic. The discussion will encompass coping strategies, the ways in which stress can be channelled in a more constructive way, and overcoming feelings of self-doubt.
Thursday 21st April 2022 7pm to 8pm: Identity – who am I away from work? This discussion will consider to what extent veterinary professionals should let their careers define them, the importance of understanding oneself in and out of a work setting, and how people can learn to value, accept, and appreciate their whole selves.
Tuesday 3rd May 2022 7pm to 8pm: Saying goodbye…letting go and learning to growThis discussion will consider how best to cope with the various types of loss that may be encountered in an individual’s professional and personal life, and how to learn, adapt and grow from these losses.
Thursday 12th May 2022 7pm to 8pm: Tackling loneliness in a hyperconnected worldThis Campfire Chat will discuss why meaningful connection and having a sense of belonging matters, and how individuals and communities can tackle loneliness in a hyperconnected world.
Angharad Belcher, Director of the Mind Matters Initiative, said: “We all lead busy professional and personal lives and sometimes it means that self-care, which includes talking to others about how we’re feeling and about issues that we find important to us, can fall by the wayside.
“Our Campfire Chats offer a perfect opportunity – and excuse – to take a bit of time out of your schedule to engage in a structured but informal discussion about all manner of subjects, expertly led by a chair and panel with experience, lived and otherwise, on the topic being talked about.
“These events are for the whole veterinary team, we keep the sessions very informal, and there is also the opportunity to share or ask questions of the panel.”
To sign up for the first session, visit https://bit.ly/3GnQK0G.
For further information about the events contact Abi Hanson, Mind Matters Initiative Officer, on a.hanson@rcvs.org.uk
The annual survey gives an overview of remuneration levels within the veterinary sector.
It covers everything from basic earnings, bonuses, dividends and overtime, to benefits such as accommodation, car allowances and pensions.
SPVS is asking everyone in the veterinary profession to take part, whether they're in a clinical or non-clinical role, a vet, a nurse, a practice manager, support staff or working in industry.
The main findings of the survey will be published in a report and freely available to any participant who gives their email address at the end of the survey.
SPVS members will be able to access the full results with additional commentary and analysis.
All survey data is treated as strictly anonymous and totally confidential.
https://www.smartsurvey.co.uk/s/LOZS6O
Any questions: office@spvs.org.uk
Skin diseases and palpable masses are a common presentation in guinea pigs brought for veterinary care2.
However, few studies have thus far looked at the prevalence of spontaneously arising diseases in pet guinea pigs.
"Lumpy bumpy guinea pigs: a retrospective study of 619 biopsy samples of externally palpable masses submitted from pet guinea pigs for histopathology" retrospectively analysed 619 biopsy samples submitted for histopathology from pet guinea pigs that had presented with externally palpable masses.
The purpose was to determine the most common tissue origins of these masses and the most frequent pathological diagnoses, together with signalment data for the most commonly diagnosed lesions.
Of the 619 samples submitted from 493 animals, 54 (8.7%) had arisen from the mammary glands3 and 15 (2.4%) from the thyroid glands, with the remaining 550 (88.9%) involving the skin and subcutis, muscle (n = 1), salivary glands (n = 4), lips (n = 2), ears (n = 4) and peripheral lymph nodes (n = 23).
Forty-seven (7.6%) of the masses were diagnosed as inflammatory in nature, including dermatitis, panniculitis, lymphadenitis, cheilitis, myositis, sialoadenitis, abscess and chronic inflammation with osseous metaplasia.
Non-neoplastic, non-inflammatory lesions accounted for a further 31 (5.0%), namely cysts, hamartomas, hyperplastic lesions, polyps, ectopic bone formation and salivary gland steatosis.
The remainder of the samples were neoplastic in nature (541; 87.4%), with 99 masses classified as epithelial in origin, 347 as mesenchymal, 23 as round cell, five as melanocytic and eight as unclassified malignant neoplasms.
Of these, mesenchymal neoplasms were further subdivided into benign (288) and malignant (59).
Lipomas were the most common neoplasm diagnosed, accounting for 286 of all samples submitted.
Of all 619 samples included in the study, the eight most commonly diagnosed lesions were lipoma (46.2%), trichofolliculoma (12.3%), sarcoma (of various subtypes: 9.5%), inflammation (all sites 7.6%), lymphoma / leukaemia (3.4%), mammary carcinoma (4%), mammary adenoma (3.2%) and thyroid carcinoma (1.5%).
Overall these eight diagnoses accounted for 87.7% of all submissions from the externally palpable masses from the pet guinea pigs submitted for histopathology.
Melanie said: “Guinea pigs are an increasingly popular household pet.
"Skin diseases, including palpable masses, are a common reason for veterinary presentation. But few studies have been published to date that provide information for clinicians about these conditions.
“This study illustrates the importance of neoplasms of the skin and subcutis in pet guinea pigs, with over 87% of the cases analysed having one of eight diagnoses.
"While most of these neoplasms are benign, a substantial minority are malignant and identifying those lesions is especially important in treatment planning.
"Clinicians dealing with pet guinea pigs should also be aware that some externally palpable masses may arise from the thyroid or mammary glands rather than the skin or subcutis, and that male guinea pigs may also develop mammary lesions.”
The paper has been selected as ‘Editor’s Choice’ by the Journal of Comparative Pathology and will be free to access until September on Lumpy, bumpy guinea pigs: a retrospective study of 619 biopsy samples of externally palpable masses submitted from pet guinea pigs for histopathology - ScienceDirect.
The company says the sessions will help veterinary staff learn more about the condition - which affects up to 20% of dogs in the UK annually1 - the causes and consequences of osteoarthritis pain, the main predisposing risk factors and the impact of chronic pain on central sensitisation.
The CPD will look at what steps practices can take to mitigate animal suffering and increase long-term owner compliance and will encourage practices to look at their current osteoarthritis management strategy.
Kai Crawshaw, Brand Manager at Animalcare, said: "Canine osteoarthritis is a growing concern for UK vets – latest figures suggest that over two million dogs are suffering, based on current population figures.
"Managing these cases can be challenging, but through this lunch and learn session, we aim to support veterinary staff and help them to expand their knowledge and implement an improved approach for managing canine osteoarthritis.’
www.animalcare.co.uk/lunch-and-learn
For the study, which was conducted in 2018 and published this year in Medical and Veterinary Entomology1, practices from around the UK sent in combings from 812 cats and 662 dogs for analysis.
28% of the cats and 14% of the dogs were found to be carrying fleas, with cats from central Wales and the Welsh Borders being more than twice as likely to have fleas than elsewhere in the country. Likewise, dogs from North Wales, the North Wales borders, South Wales and South West England were between 3 and 4.5 times as likely to have fleas as elsewhere.
Of the cats treated with fipronil, 62% (n=57) were still found to be carrying fleas despite treatment. Of the dogs, 44% (n=49) of those treated with fipronil were still carrying fleas. By contrast, 4.1% of cats and 1.4% of dogs treated with fluralaner (Bravecto) were found to have fleas (the lowest of any treatment).
Professor Richard Wall, Veterinary Entomologist at the University of Bristol said: "There is a clear need for greater owner education about the importance of flea treatment and a better understanding of the efficacy of different flea and tick prevention products.
"It is critical for vets to not only recommend the best product for a pet’s needs but to also give a better understanding of the effectiveness and correct application of the different treatments."
Photo: Professor Richard Wall, University of Bristol
The training sessions are taking place both online and in person and places will be allocated on a first come first served basis.
Upcoming training dates are as follows:
https://www.vetmindmatters.org/training/
The Pitpat was designed in Cambridge, launched in 2016 and is now the leading dog activity monitor on the market, with over 50,000 sold.
I was invited to review the Pitpat by one of the company's non-executive directors, Myra Forster-van Hijfte FRCVS, a European and RCVS Specialist in Small Animal Medicine who was also one of the angel investors.
I wasn't convinced that this was something every dog owner would want to use regularly. You'd have to be a bit obsessed to be routinely reviewing the activity levels of a perfectly fit young dog. But I think there is real potential for it to add value to veterinary nurses' obesity clinics and also to measure a response to treatment for things like osteoarthritis (OA). As such, it is perhaps something for practices to consider buying for themselves, and then loaning it out to the owners of dogs on a weight loss programme or which are getting treatment for OA.
Myra said: "PitPat gives an objective measurement of the actual activity the dog has done and the app gives the owner tailored advice (based on breed, age and sex of the dog) on how much exercise their dog should be doing and an estimate of daily calories their dog has burnt. This will help owners keep their dogs fit and healthy and in the correct body condition.
"PitPat is useful in weight management clinics by improving owner engagement through the associated weight app. Encouraging exercise also provides the owner with a positive contribution towards weight management.
"Monitoring activity pre- and post treatment, for instance dogs with osteoarthritis on NSAID's, provides vet and owner with an objective measure of whether treatment is effective or not."
You can watch the full review here. If you're interested in technology that is designed to make life easier, do subscribe to the channel!
For more information about Pitpat, visit: https://www.pitpat.com/. Veterinary practices that want to buy a Pitpat for use with their clients will get a trade discount. Contact the company for more details.