Faecal calprotectin is a calcium-binding protein released into the gut lumen predominantly by neutrophils, and to a lesser extent by monocytes and macrophages, during intestinal inflammation.
Its presence in faeces reflects the degree of neutrophilic infiltration in the gut mucosa, making it a useful biomarker for identifying intestinal inflammation.
Faecal calprotectin lateral flow testing is already used in human health and included in the NICE guidelines for the management of inflammatory bowel disease (IBD)1.
Determining the underlying cause of chronic diarrhoea, vomiting and weight loss in cats and dogs can be complex, often requiring invasive procedures such as endoscopy or biopsy - both of which carry cost, risk, and sometimes practical limitations in general practice.
GIQuest is designed to offer a non-invasive, rapid alternative to support clinical decision-making.
Carus says that whilst not a replacement for histopathology, faecal calprotectin concentrations have been shown to correlate with disease severity in dogs and cats, as measured by tools such as the Canine Chronic Enteropathy Clinical Activity Index (CCECAI).2
New data from the University of Bristol Vet School appears to confirm the test’s ability to differentiate dogs with histologically-confirmed inflammatory enteropathy from healthy controls with high sensitivity (94%) and specificity (96%) using a score threshold of 3mg/kg.2
Carus says the test also performed well in cats, distinguishing those with inflammatory enteropathy from healthy controls with a specificity of 100% and sensitivity of 92%.
In addition, the test detected elevated calprotectin levels consistent with inflammatory gastroenteropathy in 25% of dogs receiving oral NSAIDs, which highlights its potential not only in long-term monitoring but also early in treatment when GI side effects may first emerge.
Jolian Howell of Carus Animal Health said: “Faecal calprotectin testing can provide additional clarity in a range of clinical scenarios.
"It is particularly useful when diagnosing and managing suspected inflammatory enteropathy or food related reactions and for monitoring or screening for GI side effects of oral non-steroidal anti-inflammatories in long term OA therapy regimes.”
The Bristol study also showed that dogs with food-responsive enteropathy had a significant drop in calprotectin concentrations following dietary change, reinforcing the test’s role in tracking treatment response.
Georgie Louca, Veterinary Business Manager for Carus Animal Health, added: ”By providing a measurable, visual indicator of intestinal inflammation, GIQuest also helps support client communication and can improve compliance during treatment or dietary trials.”
GIQuest is designed for use in practice, including during consultations, delivering colour-coded results in 15 minutes.
GIQuest is now available to veterinary practices across the UK and can be ordered through veterinary wholesalers NVS, Covetrus and MWI.
https://carusanimalhealth.com/giquest
References
David, Appleton Professor in Equine Surgery, University of Florida (pictured, left), says that despite considerable progress since the 1970's, largely through improved understanding of the diseases involved, diagnostic methods, surgical equipment and materials, and specialised training of surgeons, lingering problems remain and need to be addressed at all levels, not just by surgeons.
He said: “The current high cost of colic surgery can deny many horses a life-saving procedure.
"Pessimism is likely the product of past failures and overemphasis of treatments that are inappropriate or misdirected.
"Delays in referral might seem minor but have devastatingly harmful effects on outcome.
"Owners, primary care veterinarians, and surgeons need to establish an approach to colic based on teamwork, education, and rejection of myths that are widely promulgated.
"I will be looking at the key elements of progress and how they can be applied for future success.”
Professor Scott Weese (pictured right) is Director of the Centre for Public Health and Zoonoses at the University of Guelph.
He will present: "Misconceptions, Myths and Dogmas: moving past old barriers to optimise antimicrobial use in horses", which will challenge the audience to think about what they do with antibiotics and why, with the aim of introducing practical steps to optimise antimicrobial use, leading to improved patient outcomes, easier treatment and minimisation of negative consequences.
Scott said: “We do a lot of things simply because we’ve done them, not because they work or make sense, and we need to look at what we’re doing and the available evidence.
"I will discuss some well-established dogmas that don’t actually make sense, cover some common questions and misconceptions about antibiotic use, and try to help us advance how we use these life-saving drugs that, to some degree, are a non-renewable resource.”
Scott will also be presenting a talk about sampling on the Friday in the antimicrobial stewardship session, with the aim of getting everyone thinking about how we make antibiotic decisions: “There’s a lot of emphasis on submitting cultures, but if we submit bad samples or can’t interpret them, it’s at best a waste of money and at worst can harm patients.”
Book before 6th August to take advantage of early bird prices for BEVA members of £599 for a three-day pass for vets (normal price £699) and £225 for vet nurses (normal price £273) (with concessionary rates available for those in their first three years of graduation or earning less than £25,000).
Day tickets and practice passes are also available.
Early bird rates and practice passes are available until 6 August 2025.
http://www.bevacongress.org
Giles is the professor of molecular neuroendocrinology at the Medical Research Council Metabolic Diseases Unit and scientific director of the Genomics/Transcriptomics Core at the University of Cambridge.
He is a well-known broadcaster thanks to his appearances on programmes such as BBC’s ‘Horizon’ and ‘Trust me, I’m a Doctor’ and author of two books: Gene Eating: The Story Of Human Appetite and Why Calories Don't Count.
He also hosts the podcast Dr Giles Yeo Chews The Fat.
Giles and his colleagues at the University of Cambridge recently identified a genetic mutation in Labrador retrievers that significantly increases their propensity for obesity and food motivation.
This mutation, a 14-base pair deletion in the POMC gene, disrupts the production of beta-MSH and beta-endorphin, hormones involved in regulating appetite and energy balance.
The study found this mutation is present in about 25% of Labradors and 66% of flat-coated retrievers, and is also more common in assistance dogs than pet Labradors.
Giles' lecture: "The genetics of obesity: Can an old dog teach us new tricks?" will lay out the evidence for a genetic basis to body weight and explore the role of the leptin-melanocortin pathway in both human and dog obesity, and its conservation through evolution.
Giles said: “It is clear that the cause of obesity is a result of eating more than you burn.
"It is physics.
"What is more complex to answer is why some people eat more than others?
"Differences in our genetic make-up mean some of us are slightly more hungry all the time and so eat more than others.
"I will highlight the fat-sensing 'leptin-melanocortin' pathway, as a key appetite control circuit.
"Not only is the pathway conserved in all mammals and many higher vertebrates, but genetic disruption of the pathway as an evolutionary strategy to influence feeding behaviour has also been conserved. In contrast to the prevailing view, obesity is not a choice.
"People who are obese are not bad or lazy; rather, they are fighting their biology.”
British Veterinary Association President Elizabeth Mullineaux said: “I’m sure our BVA Congress delegates will appreciate both Dr Yeo’s scientific knowledge and his dynamic delivery style and I’m personally looking forward to learning more about this exciting topic.”
https://london.vetshow.com