A research project funded by equine charity The Horse Trust has succeeded in killing equine sarcoid cells in vitro by silencing a gene in the virus that causes sarcoids. The researchers are now hoping to obtain funding for clinical trials using the new technique, which could result in a more effective, non-toxic treatment for sarcoids.

Sarcoids are skin tumors caused by infection with the Bovine Papillomavirus (BPV). They are the most common type of tumour found in horses - the estimated prevalence in the UK is 6-7%. Although the disease is rarely life threatening, many horses with sarcoids are euthanased because the condition is untreatable or because the horse is unsellable. Currently there is no universally effective treatment for sarcoids and if treatment fails the sarcoids will often come back worse.

However, research that was given funding by The Horse Trust offers a potential ray of hope for owners of horses affected by sarcoids. The research was published in Virus Research journal earlier this year.

The research, which was led by Professor Lubna Nasir of the University of Glasgow, found that by inhibiting the activity of a particular viral protein within sarcoid cells, the amount of viral DNA in the cells reduced. This led to a reduction in the growth of the sarcoid cells and caused the cell to die by Programmed cell-death (PCD). The researchers believe that PCD occurs because the sarcoid cells become reliant on the virus.

Professor Nasir said: "This could potentially be a major breakthrough in the treatment of sarcoids. We are now seeking funding to use this technique in clinical trials on horses that have sarcoids."

The research team inhibited the activity of a viral protein called E2, which is needed by BPV to replicate. They used a novel approach termed 'gene silencing' to suppress the activity of the gene that codes the E2 protein. The research was carried out in vitro on fibroblast cells, which had been cultured from sarcoid tissue removed from animals during surgery.

As this research was carried out in vitro, the researchers will now need to see if they can replicate the results in vivo, by developing a way of targeting the sarcoid cells in horses.

"One of the challenges with gene silencing is administering it within clinical setting - as you need to get molecules into every cell. As sarcoids are on the surface of a horse, we think administration should be relatively easy - potentially by injecting or applying a cream to the sarcoid," said Professor Nasir. "If we are able to successfully develop this technique it would be a non-toxic and easy to administer treatment for horses affected by this distressing condition."

Nasir's research could also have an impact on the treatment of lesions in cattle, which are also caused by BPV. Around 50% of cattle in the UK are estimated to have lesions. It may also help with the treatment of Human Papillomavirus (HPV) infections in humans. HPV, which is similar to BPV, can lead to various cancers in humans including cervical and vaginal cancer.

Paul Jepson, Chief Executive and Veterinary Director of The Horse Trust said: "We are really excited that the research we have funded could lead to a major breakthrough in the treatment of sarcoids."

Veterinary Nurses are being invited to comment on National Occupational Standards (NOS) as Lantra, the Sector Skills Council for environmental and land-based industries, announced today that further consultation meeting dates have been set for January and February.

Individuals and organisations representing veterinary nursing are being invited to get involved in shaping the NOS for their industry and ensure they accurately reflect today's way of working and the role of veterinary nurses in practice.

Lisa Jarvis, Lantra's Partnership Manager for veterinary nursing and a RVN herself, said: "NOS identify the detailed knowledge, understanding, ability and experiences somebody needs to carry out their job effectively. Lantra works hard with industry to make sure they fit their needs and is continuing the consultation process by holding a number of additional meetings in January and February."

The additional meetings will take place at Antrim, Northern Ireland (12 January, 11.00 to 14.30), Lantra House, Warwickshire (14 January and 17 February, 10.30 to 15.30) and a meeting at the College of Animal Welfare in Edinburgh, Scotland (23 February).

Lisa Jarvis continued: "These newly added meeting dates will give all those interested parties, who missed the first set of meetings, the opportunity to come along and define the standards for today's veterinary nurse. We want as many people to get involved as possible but if you can't join us at a meeting, you can register with us to take part in the online consultation that will follow later in January and February."

Lantra ensures that all industries represented in their footprint have up-to-date and accurate National Occupational Standards. The standards help businesses improve performance and productivity as they can be used to identify the skills needed for their workforce, highlight best practice, develop training and recruitment plans and develop job descriptions.

If you would like to take part in any of the meetings or the online consultation to help industry get the most out of the skills system, please visit www.lantra.co.uk/nos, call Lantra on 02476 858 424 or register your interest by emailing standardsandquals@lantra.co.uk.

Dorwest Herbs has highlighted research that suggests a highly rational mode of action for kelp seaweed as an aid in the treatment of obesity when used alongside a weight reduction diet. The company is asking vets and nurses to look at the evidence and consider using licensed herbal medicines to help cats and dogs lose weight naturally. To help you evaluate the product, Dorwest is giving away 50 trial packs of Kelp Seaweed Tablets.

Mary Boughton MBE, Quality Director at Dorwest Herbs and the UK's leading specialist in the formulation of veterinary herbal medicines said: "We have lots of evidence that Kelp Seaweed Tablets work as an aid in the treatment of obesity but traditional explanations were based on the effect of iodine supplementation on thyroid function as a mode of action. That just didn't hold water for us. However, in common with many conventional medicines, the mechanisms for mode of action of herbal medicines are often not known. So, it was with some excitement that we heard of research that demonstrated that fucoxanthin, a pigment found in kelp, upregulates expression of UCP1 (uncoupling protein) and produces weight loss in the same region as conventional anti-obesity drugs."

Various studies estimate pet obesity may affect 30 to 60 per cent of pets in the UK and arthritis, heart disease and diabetes are just some of the diseases that occur with increasing frequency in obese pets. The research indicates that fucoxanthin has an effect on glucose metabolism and may lower the risk of coronary heart disease in humans. Phlorotannins found in brown seaweed have also recently been indentified as interfering with both the onset and consequences of osteoarthritis. Mary Boughton points out that multiple effects are often seen when herbal treatments are used, "Herbal treatments contain thousands of plant derived chemical compounds and are known for their diverse action, as opposed to the 'magic bullet' effect seen with conventional medicines. In a condition such as obesity where we see many disruptions of normal metabolism and several co-morbid conditions, choosing a herbal treatment makes sense. Kelp Seaweed Tablets are the logical alternative."

Dorwest has prepared a fully referenced technical information sheet detailing recent scientific studies and data from herbal formularies with reference to the role of kelp seaweed in obesity management.

To help vets and nurses further evaluate Kelp Seaweed Tablets - a licensed herbal medicine - used as part of a weight management programme the company is giving away 50 FREE trial packs containing seven weeks of Kelp Seaweed Tablets for a large breed dog, a case report sheet and the technical information sheet. There is also a prize of £100 of John Lewis shopping vouchers for the most informative case report received before the end of February 2010.  There is one pack available per practice, while stocks last.

To request a technical information sheet or pack call Dorwest Herbs on 01308 897272.

A Dogs Trust Glasgow resident who made the news last January for being so obese he could not even walk has lost almost half his body weight.

Patch, a six year old Beagle Cross, weighed the same as an average six year old child - 4.5 stones (28.45kg) - when he was brought to the Rehoming Centre last year.

Staff desperately hoped 2009 would see him find a new home and see him shed almost half his bodyweight to reach his goal of 2.4 stone (15kg). After finding a new home with the MacLean family in Motherwell, exactly one year after hitting the headlines Patch is within sniffing distance of his target by weighing in at 2.9 stone (18kg).

Vets had warned that a rapid weight loss would put strain on Patch's organs and could actually harm him, so it has been a slow, careful process. He follows a strict diet and his exercise levels have been built up gradually, with careful monitoring by veterinary staff.

Claire Kelman, Dogs Trust Glasgow Assistant Centre Manager, said: "When Patch first came to us he was so obese he couldn't even walk and needed a sling to be moved from one place to another. Now he's lost the weight he can run around and properly enjoy his walks like any other dog.

 It just goes to show a good diet and careful exercise can make a real impact, so maybe he can be a shining example for everyone feeling a bit bloated after the Christmas break!"

 Images courtesy Centre Press Agency

The Kennel Club has broadly welcomed Professor Sir Patrick Bateson's 'Independent Inquiry into Dog Breeding', which has recommended that steps be taken to tackle irresponsible breeders and to change the way the public think about buying dogs. 

The Kennel Club, which commissioned and funded the report in conjunction with Dogs Trust, welcomes the report's focus on irresponsible breeders who farm puppies with little concern for their welfare and those who sell poorly socialised puppies on to owners to use as 'status dogs' or as fighting weapons.

The Kennel Club agrees that additional training and support needs to be given to local authorities, which are responsible for issuing breeding licences to those people who breed five or more litters of puppies in a single year, as the current provisions are deemed to be ineffective. It agrees that compulsory microchipping of dogs and increased public education to stop people falling prey to puppy farmers and to help them find responsible breeders are necessary.

It is also glad that the report recognises the need for a 'robustly policed and well respected quality assurance scheme', consisting of breeders that buyers can trust to look after their puppies' health and welfare, and that it suggests that the Kennel Club's Accredited Breeder Scheme, with some modification could be used. 

However, the Kennel Club is concerned that the report could have gone further and that its recommendations do not appear directly to cover those breeders who breed less than five litters per year and who are not part of the Kennel Club Accredited Breeder Scheme. The Kennel Club would have liked to have seen a recommendation for regulation to ensure that these breeders follow higher standards, such as compulsory health testing. 

Caroline Kisko, Kennel Club spokesperson, said: "Whilst the report recognises that the majority of breeders are responsible, there are those whose actions are bringing the rest of the dog breeding community into disrepute and this needs to be stopped.

"We are glad that the report recognises that the Kennel Club has made a good start in its efforts to unite responsible breeders within its Accredited Breeder Scheme, for the benefit of puppies and puppy buyers, and we believe that this should be the basis for moving forward. We are currently working towards UKAS accreditation of the scheme as suggested by Professor Bateson.

"We agree that responsible breeders should be rewarded and believe that the show ring is the best forum for this. The report recognises that 'dog showing and judging are a powerful lever for change' and the Kennel Club is dedicated to ensuring that only the healthiest dogs are rewarded at shows.

"Public education is vital and all dog welfare organisations must continue to work together to ensure that people know what to look for when buying a dog."

The report looks at genetic diversity in breeds and recognises that the Kennel Club has banned close matings. It advises that future decisions about matings that could affect genetic diversity should be 'breed specific' and made upon evidence based scientific information and advice. To this end it is recommended that the veterinary profession should gather data to show the prevalence of certain diseases and that an advisory council should develop evidence based breeding strategies.

Mrs Kisko continued: "The Kennel Club has long recognised that genetic diversity plays a crucial role in safeguarding the health of dogs and the report is absolutely right to suggest that there are no further blanket rules in place but that decisions are based upon scientific knowledge and are made on a breed by breed basis. This is why we are well on the way to creating a new database which will revolutionise the way that we record dog health data. The data will enable us to bring out our Mate Select programme, which will help breeders to find suitable mating pairs which are most likely to produce healthy offspring. The database will go further than the report's recommendation, as the data will be attributable to specific dogs, rather than being anonymous, and will give us a better picture of the health of pedigrees and crossbreeds. Such knowledge is critical and will enable us to provide information to breeders, vets, geneticists and ultimately the puppy buyer. 

"We are keen to harness as much knowledge as possible for the benefit of dogs so we welcome the principle of an advisory council whose members will work with the Kennel Club to advise on decisions about breeding and health. A structure already exists in the form of the Kennel Club's Dog Health Group with its recently extended remit. Additional independent experts include canine and human geneticists, veterinary surgeons and an epidemiologist. Using this framework for establishing the advisory council under an independent chairman would save significant sums of money, which can instead be devoted entirely to the dog health research that the report identified as being in 'urgent' need of more funding."

The Kennel Club and Dogs Trust will now arrange a meeting between all relevant parties in order to move forward with the recommendations from all three reports.

The full report may be downloaded at www.dogbreedinginquiry.com

The Animal Health Trust has announced a research project which aims to improve the way dogs are treated for cancer. As part of the project, the charity is appealing to veterinary practices to send samples taken from dogs diagnosed with cancer.

Using the samples, the AHT's Oncology Research Group aims to develop prognostic tests for a number of canine cancers. These tests will assist veterinary professionals in predicting how individual tumours will behave and respond to treatment. It means that each dog will be offered the best treatment for its individual case, ensuring that dogs which do not require aggressive therapy are spared the rigours and possible side effects associated with such a treatment.

The samples required are surplus small pieces of the biopsies of suspected tumours, collected for diagnostic histopathology. Cheek swabs, or blood samples that are surplus to those that are often collected for standard clinical investigations are also required. Samples will be submitted for research only with the written consent of each dog owner.

Mike Starkey, from the AHT's Oncology Research Group, said: "To make progress we need to collect many samples of many different tumours. We simply need vets to send us freshly frozen (not fixed in formalin) biopsies of suspected tumours."

Samples of the following tumour types are needed from the following breeds:

• Boxer - lymphoma, glioma mammary tumour, mast cell tumour
• Bullmastiff - lymphoma
• Cocker Spaniel - mammary tumour
• English Springer Spaniel - lymphoma
• German Shepherd Dog - mammary tumour, haemangiosarcoma
• Golden Retriever - mast cell tumour, melanoma, soft tissue sarcoma
• Irish Wolfhound - osteosarcoma
• Labrador -  mast cell tumour, melanoma, soft tissue sarcoma
• Poodle (miniature, standard and toy) - melanoma
• Rottweiler - histiocytic sarcoma
• Schnauzer (giant, miniature and toy) - melanoma
• Scottish Terrier - melanoma
• Weimaraner - mast cell tumour

Sue Murphy, the AHT's Head of Oncology, said: "We know cancer is a major cause of death in dogs. The research we are doing here will arm us all with the ability to make better informed decisions about the right course of treatment for each patient."

The samples will also aid with the AHT's research into inherited genetic defects. Researchers are investigating to find out why certain pedigree dogs have an increased risk of developing a specific cancer. The AHT is part of a European research group working on the 'LUPA project' which aims to develop DNA tests to identify dogs which carry the mutations. This should enable breeders to alter their breeding strategies to reduce the incidence of dogs affected by those cancers. It will also allow vets to carefully monitor dogs who have an increased risk of developing cancer.

Mike Starkey added: "The help from veterinary practices and dog owners is invaluable in this research. Without the samples we're unable to progress our work."

If you would like further information about the project, please contact Mike Starkey on 01638 555603 or email mike.starkey@aht.org.uk

The parasitologist Maggie Fisher is coordinating a survey across the UK on behalf of Bayer Healthcare, to test the efficacy of their flea treatment 'Advantage'.

She is looking to enlist some new practices to help her collect field strains of flea eggs in return for payment of £40 per sample.

If you are regularly seeing flea ridden cats or dogs and could help collect one or more samples of flea eggs by the end of November then please contact Jo Goodman on 01594 530809 or email her at Jo@ridgewayresearch.co.uk.

The Competition and Markets Authority has opened a review of the veterinary sector after concerns that pet owners are paying too much or not being given enough information to make an informed decision. 

Asked why the CMA had decided to launch the review, its Senior Director for Consumer Protection told BBC R4's Today programme this morning that: "the costs of many vet services are rising higher than the cost of inflation, and it can be really hard to find out how much it's going to cost you, both for routine treatments or if something goes wrong and you need to find emergency care for your pet."

George added: "There's many other [veterinary] services and costs that people cannot have predicted and they can find themselves unexpectedly facing some really high bills, and when other household bills are going up very steeply at the moment we want to do everything we can to make sure that people can predict how much it is going to cost to see a vet, both for routine stuff but also for things if there's a crisis."

The authority is also looking at whether there is enough transparency over practice ownership.

With the percentage of independent practices falling from 89% in 2013 to 45% by 2021, the authority says people may not be clear if their vet is part of a group which owns other vet practices in their area or that the services which are being sold to them (such as diagnostic tests or treatments at a specialist animal hospital) are provided by that group.

This, it says, could impact pet owners’ choices and reduce the incentives of local vet practices to compete.

The CMA is now asking veterinary professionals, people who supply veterinary products and services and pet owners to take part in the review by completing an online questionnaire: https://www.gov.uk/guidance/how-to-respond-to-the-veterinary-services-market-for-pets-review 

In particular, it wants to hear practitioners' experiences of:

• Pricing of services, including whether pet owners were aware of how much a treatment would cost, and how they pay for it (whether they pay themselves or via insurance)
• How prescriptions and medication for pets are arranged and sold
• Choosing a vet surgery and whether people are aware that their vet may be part of a larger chain which might also own other surgeries in the area
• Using out-of-hours and emergency vet services where options might be limited

The questionnaire will remain open for six weeks.

The CMA will outline the issues it identifies and announce its next steps early in 2024.

Pooch & Mutt has 20x 40-day trials of its new joint & bone supplement, Mobile Bones Concentrate, to give away to veterinary professionals.

Guy Blaskey from Pooch & Mutt said: "At The London Vet Show vets and vet nurses told us that they loved the new Mobile Bones Concentrate because at just £9.99 per month it costs less than other joint supplements (whilst having the same high quality ingredients), it takes up a very small amount of shelf space and it doesn't involve the client having to either change their dog's food or stuff pills down their dog's throat."

In response to requests from vets and vet nurses to try the new joint supplement, Pooch & Mutt have set up a dedicated website at www.jointsupplementfordogs.com where you can apply from one of twenty 40 day trials.

Guy continued, "We did not want to simply send samples out to everyone. By setting up the site we can choose a variety of dogs from different breed and with different conditions to send a full 40-day trial to. We hope to get regular feedback from the vets, vet nurses and dog owners involved in the trial and publish it on http://www.jointsupplementfordogs.com/ for everyone else to see."

The trials are available to all veterinary professionals and can be for their own dogs, or dogs belonging to their clients.

Eskimo, a reindeer at Edinburgh Zoo has received life-saving surgery just in time for Christmas, making him the first reindeer in history to receive keyhole surgery.

Vet Romain Pizzi successfully removed one of Eskimo's testes, which had been lodged in its abdomen since birth, using specialist surgical instruments donated to the zoo by one of Ark Surgical's strategic partners Surgical Innovations.

The zoo was worried that the retained testicle may have been developing into a tumour giving off abnormal hormones, and that this could become life-threatening. Thankfully, zoo surgeons found that the retained testicle, although abnormally sized, had not yet developed a tumour.

It is thought that the abnormal testicle was affecting Eskimo's production and flow of testosterone and, as a result, he was showing submissive behaviour and being bullied by the other male reindeer in the herd. He had also started to show some abnormal and delayed antler growth and development. Removing the testicle will halt any abnormal hormone production so hopefully Eskimo will return to full vigour just in time for Christmas.

Gavin O'Brien, Director at Ark Surgical said: "We were only too happy to help when Romain mentioned the challenging operation faced by Eskimo and in the season of goodwill we approached Surgical Innovations who kindly donated the instruments for this pioneering surgery." 

Although laparoscopic surgery is routine in humans, the standard procedure in animals is still open abdominal surgery.  Open abdominal surgery is 20 years behind human medical advances and has a number of negative factors on animals such as more post-operative pain, slower recovery and a higher risk of post-operative complications and infections.

Romain, a veterinary surgeon for the Royal Zoological Society of Scotland, based at Edinburgh Zoo, said: "Laparoscopic surgery is still very uncommon in veterinary medicine, even amongst common species such as dogs, cats and horses, so for keyhole surgery to be carried out on a reindeer shows a great advancement in veterinary surgery."

It is estimated that nearly one out of every two households in the UK are pet owners. Veterinary surgeons perform on average 600,000 open abdominal procedures annually but it is believed that less than 1% of vets currently practice laparoscopic surgery. 

Romain believes that with the right instrumentation available through innovative companies such as Ark Surgical, UK vets now have more opportunity than ever to introduce laparoscopic techniques as part of their operating procedures.

Romain said: "This procedure was only really possible thanks to a cutting-edge designed retractor which we were able to use in this case. Ironically although a reindeer is a reasonably large animal, due to their unique anatomy and massive four chambered stomach that takes up most of the space in the abdomen, there is a very limited internal operating space. For this reason the operation was much more difficult than in a human, or in a dog, where there is more space to work, despite their smaller size."

"We were especially pleased with how quickly Eskimo recovered after surgery, he was standing and happily eating lichen again within 10 minutes of recovery from anaesthesia. He hardly seemed to notice he had even had surgery, although he was still slightly groggy from the anaesthesia. This would simply not have been possible with traditional open abdominal surgery, as the long wound would have been much more painful and debilitating."

The minimally invasive nature of laparoscopic surgery means there are numerous benefits for animals such as a reduction in post-operative pain, a faster recovery and reduced post-operative care.   It also has a decreased risk of infection after surgery and a lower risk of any wound complications. 

For veterinary surgeons laparoscopic surgery can offer better visualisation of the operated area, allowing them to be more precise and reach areas that are difficult to see in open surgery such as the liver and pelvic canal.

Romain carries out laparoscopic operations on dogs, cats and exotic pets at his own veterinary practice Inglis Veterinary Centre (Scotland) and has pioneered several new laparoscopic techniques.

He said: "Laparoscopic surgery has so many benefits for the animal, the veterinary surgeons and the zoo, so there is no reason why it should not be more common practice within veterinary surgery.  I hope Eskimo's experience helps raise its profile and encourage more veterinary surgeons to look in to it as a standard surgical procedure."

Ark Surgical offers a wide range of laparoscopy instruments and peripherals to vets across the UK and to suit all budgets. The company says it is already working with many of the UK's leading vets and agencies such as the Royal Zoological Society of Scotland, as well as the UK foremost laparoscopic medical device manufacturer Surgical Innovations, to be at the forefront of veterinary laparoscopic surgery

For more information on animal laparoscopic surgery contact Ark Surgical on 01732 862882 or http://www.arksurgical.co.uk/

The National Association of Veterinary Physiotherapists (NAVP) is calling for the Royal College of Veterinary Surgeons (RCVS) to establish an independent register of veterinary physiotherapy practitioners. According to the Association, such a register would eliminate individuals practicing without proper training and qualifications and raise the standard of veterinary physiotherapy by providing a disciplinary role.

NAVP President and leading veterinary anatomist Dr Sue Kempson is heading the NAVP campaign for the establishment of an independent register. In a letter to the President of the RCVS, Dr Kempson said: "Recognition by the veterinary profession of the role of physiotherapy in post-operative rehabilitation and in supporting both companion and performance animals is growing. However, we do believe that referring veterinary surgeons are increasingly faced with a dilemma caused by the wide differential between qualifications offered by the various organisations representing practitioners in areas such as physiotherapy. There is an urgent need for a distinction to be made between these different types of qualification. To this end, there should be a clearly defined independent register of practitioners with appropriately validated qualifications which are clearly understood by the veterinary profession."

In partnership with Harper Adams University College, the NAVP has introduced a fully-validated post-graduate course in veterinary physiotherapy which offers a choice of Post-Graduate Diploma or Masters Degree. Only one other professional body, the Association of Chartered Physiotherapists in Animal Therapy (ACPAT) currently offers a similar qualification at this level.

Dr Kempson said: "The establishment of a register of physiotherapists would greatly assist vets and their clients to make informed decisions on their choice of therapist. It would eliminate those individuals without proper training and qualifications and help raise the standard of veterinary physiotherapy by providing a disciplinary role. At present there are no sanctions on those people practicing without the necessary qualifications or those whose work is sub-standard or who are guilty of professional misconduct.

"We do not believe that such a register should rest with any individual professional body or be affiliated to specific educational courses. To have authority, it requires independence and a register held under the auspices of the Royal College of Veterinary Surgeons would carry the credibility that the veterinary profession requires."

Virbac Animal Health has launched a new pet owner information pack to help practices raise awareness of reproductive health issues in dogs and cats.

The pack consists of a leaflet holder with four different leaflets covering unwanted sexual behaviour, castration, prostate disease and misalliance. The holder has a small footprint so will sit nicely in any practice reception area.

Product manager Chris Geddes MRCVS says that the pack will make it easier for vets and VNs to raise the sensitive issue of pet reproductive health with owners. "For example, prostate disease in men is well documented and public knowledge is high, but we believe that few people know that it can affect pets too.

"It is estimated that 80% of male dogs over the age of five suffer from prostate problems, but experts agree that it is underdiagnosed at present. This is possibly due to a combination of a lack of awareness and client unease on discussing reproductive subjects at their vet practice."

To obtain your free pack or for further information, please contact your local territory manager or call Virbac on 01359 243243.