https://www.vetnurse.co.uk/f/nonclinical-discussions/29947/fresh-frozem-plasma-when-to-defrost Its been a while since Ive used this. I need to prepare this for tomorrow for a patient in the morning. I remember defrosting in lukewarm water for half an hour before use. Is this correct? I was told to defrost overnight but it&#39;s to be used within 4en-USTelligent Community 10https://www.vetnurse.co.uk/thread/166787?ContentTypeID=1Mon, 24 Oct 2016 23:45:39 GMT1a0763ec-3885-442c-853e-6cef656dfec5:8f6f87c4-a194-408e-844a-1694eba69cfcPenny Gilbert RVN <p>Plasma should be complexly defrosted and bought to room temp I use a warm water bath using a plastic wallet to make sure there&#39;s no contamination of the ports. I also stress that&#39;s when it&#39;s frozen/ thawing it&#39;s very brittle and should be handled very carefully. I have only ever defrosted it a shortish period before use ie not over night not sure if you can leave it over night ? It will defo defrost within an hour or so like I said just be careful and I invert it gently but regularly :) I hope the patient is okay and it goes well x</p><div style="clear:both;"></div>https://www.vetnurse.co.uk/thread/166786?ContentTypeID=1Mon, 24 Oct 2016 23:37:43 GMT1a0763ec-3885-442c-853e-6cef656dfec5:ac96bfa7-8812-4585-850e-89872b8e06f4Steph Worsley<p>sorry for the delay in replying. you are correct in thinking that it takes about 20-30 mins to defrost in luke warm water. defrosting it and leaving it for any length of time can affect the factors (not all but some)&nbsp;</p> <p>Really an FFP transfusion should be done prior to any surgery to allow the factors to start circulating adequately not really something that should be done during.</p> <p><a href="http://www.petbloodbankuk.org/media/4720/ppb_datasheet_ffp_v3.pdf">http://www.petbloodbankuk.org/media/4720/ppb_datasheet_ffp_v3.pdf</a></p> <p>here&#39;s the data sheet for you</p><div style="clear:both;"></div>