https://www.vetnurse.co.uk/f/nonclinical-discussions/14469/dom-peth-pre-med-in-catsHas anyone experienced a cat becoming hypersensitive following a medetomidine and pethidine pre-med. Usually the combination works really well to settle them, but had a patient that it seemed to have the opposite effect on. I triple checked the dose anden-USTelligent Community 10https://www.vetnurse.co.uk/thread/117911?ContentTypeID=1Sun, 31 Jul 2011 21:03:56 GMT1a0763ec-3885-442c-853e-6cef656dfec5:68655c22-45ea-41f6-b56c-3863cf48d579Sal the 1st<p>I have never used or seen this combination used but I have seen a couple of cats that have gone&nbsp; absolutely loopy post # repair where peth has been given as an analgesic if that helps at all?</p><div style="clear:both;"></div>