Propoclear- Injection reactions.

Re: Propoclear- Injection reactions.

Gem Sprague — Sat, 06 Feb 2010 06:28:03 GMT

Hi,

Yes we have noticed this at our practice too when we have a trial of it a few weeks ago. Some of our vets also didnt like the thickness of the Propoclear too, and didnt like the resistance it gave when being injected.

Gem

Re: Propoclear- Injection reactions.

bongo — Fri, 05 Feb 2010 18:05:04 GMT

The two times I have noticed it to appear to hurt is when the animals have had patent i/v catheters in. Im not too keen on it myself as I also find it takes longer to get the animal to a suitable anaesthetic plane, blinking still for a while afterwards and still very puffy. could just be me....

Re: Propoclear- Injection reactions.

Claire Cameron — Thu, 04 Feb 2010 10:10:29 GMT

[quote user="charliv"]We will try warming the Propoclear first see if that makes a difference (we have never used it when its has gone cold and very cloudy tho). [/quote]

If the container is stored for an extended period below 20oC, the clear emulsion might become cloudy. Ensure that the product is clear before administration. Gentle warming and agitation will speed the process.

Ensure that the product is clear before administration.

http://www.noahcompendium.co.uk/Fort_Dodge_Animal_Health/PropoClear/-49853.html

[quote user="charliv"]The only reaction that we have had is the pain on injection. [/quote]

On rare occasions pain on injection has been observed, associated with perivascular administration.

http://www.noahcompendium.co.uk/Fort_Dodge_Animal_Health/PropoClear/-49854.html

[quote user="charliv"]We haven't noticed the breath holding as all our patients are put onto a ventilator[/quote]

During induction of anaesthesia, mild hypotension and transient apnoea similar to effects with other intravenous anaesthetic agents may occur. When using PropoClear, facilities for the maintenance of a patent airway and artificial ventilation should be available. In case of apnoea or hypotension, oxygen supplementation (or enrichment) must be readily available.

http://www.noahcompendium.co.uk/Fort_Dodge_Animal_Health/PropoClear/-49854.html

Re: Propoclear- Injection reactions.

Charlotte Fitzgerald — Wed, 03 Feb 2010 12:08:08 GMT

Thanks to everyone for your comments, its good to know its not only happening for us. The only reaction that we have had is the pain on injection. We haven't noticed the breath holding as all our patients are put onto a ventilator. We haven't noticed them waking up any quicker compared to the normal propofol.

We will try warming the Propoclear first see if that makes a difference (we have never used it when its has gone cold and very cloudy tho).

On the occasion that the dog howled the other day when we started to give it we set up the i/v fluids and run the propoclear through the drip line and this seemed to be more comforatble for the patient, so that might be worth considering for those practices that are going to stick with it.

Thanks again for all the comments, keep them coming.

Re: Propoclear- Injection reactions.

Felicity Caldwell — Tue, 02 Feb 2010 22:31:15 GMT

I have definatley noticed this - however it seems to be when the Propoclear has been drawn up ready in the syringe in preparation (it has been sitting in the syringe 10mins or so before induction.) ??? All our patients have i/vs placed beforehand and there has definatley been the occasional patient pulling their leg back as it is injected....

??Not sure why though

Re: Propoclear- Injection reactions.

Fiona Leathers — Tue, 02 Feb 2010 22:06:20 GMT

We've been using it since it came out and not had any problems. Breath holding can be reduced by administering it slowly just the same as the normal propofol, not had any go perivascular so can't comment.

Re: Propoclear- Injection reactions.

S-J — Tue, 02 Feb 2010 21:47:46 GMT

ahh thanks for the note about patients waking during transfer, i thought i was getting paranoid tripple checking all my anaesthetic settings.

Re: Propoclear- Injection reactions.

Nick Shackleton — Tue, 02 Feb 2010 21:17:13 GMT

We've swapped completely to Propoclear. ALL our patients get an I/V catheter placed prior to induction (don't like the idea of off the needle inductions) have seen reaction in a few patients (much like those seen with the new multi-inject bottles of vetergesic), ie some react and others don't. Have also seen more recurrence of patients waking up when being transferred to theatre.

If Propoclear is kept in cool places it will go cloudy and precipitate. This should NOT be injected. The bottle should be warmed and allowed to go clear before drawing up and injected.

Re: Propoclear- Injection reactions.

Laura Dickson BSc(Hons)RVN A1 Dip(HE)CVN DipAVN — Tue, 02 Feb 2010 21:10:45 GMT

Just a thought . . . it could possibly be the preservative in it that makes it sting when injected. When Vetergesic multivials first came out the same thing was noticed and it was put down to the preservative.

Re: Propoclear- Injection reactions.

Emma Bartlett — Tue, 02 Feb 2010 19:10:41 GMT

I had propofol twice last year.......they injected lidocaine i/v before the propofol was given. Not sure if they were using the clear stuff as i was trying not to pass out pre induction due to my irrational cannula phobia !!!(no problems putting them in creatures, just when they come near my veins)

Re: Propoclear- Injection reactions.

Rhian Davies — Tue, 02 Feb 2010 17:50:09 GMT

we had one bottle in our practice to try but were finding, pain on injection, breath holding and a much worse anaesthetic so we went back to propofol after that after we all agreed it wasn't worth it

Re: Propoclear- Injection reactions.

S-J — Tue, 02 Feb 2010 17:43:44 GMT

we have been finding that the veins "blow" a lot more often plus there does seem an increase in the amount of dogs breath holding. i still dont like that its clear though, i know that i have drawn it up and handed it directly to the vet who gives it straight away but i still panic that its something else

Re: Propoclear- Injection reactions.

karen2010 — Tue, 02 Feb 2010 17:39:04 GMT

my working coker had a reaction to it! his leg was swollen for days after, also had another dog in practice with the same reaction & in both cases don't think any went perivascular!

Re: Propoclear- Injection reactions.

Vicky RVN — Tue, 02 Feb 2010 17:38:24 GMT

Oh no by the sounds of it i'm not looking forward to us swapping over We've got a big stock of propofol so using it up first.

Re: Propoclear- Injection reactions.

lskm 23 — Tue, 02 Feb 2010 17:31:37 GMT

We have found that we do get more reactions, I have also thought that we get more severe breath holding with it also.

We have also seen some large swelling in the legs if the cat has struggled and gone perivascular.

Re: Propoclear- Injection reactions.

Charlotte Fitzgerald — Tue, 02 Feb 2010 15:15:06 GMT

It interesting you say that about your reactions being when the propoclear is cold, the reactions we have had are only recent, no reactions when we first started using it so maybe it is the reduction in temperature that could be causing it. I will try warming it and see if that makes a difference.

Re: Propoclear- Injection reactions.

Maisy — Tue, 02 Feb 2010 14:59:49 GMT

Had a couple of cats react to it (venous not perivascular), dogs have been no problem though.

Re: Propoclear- Injection reactions.

loobylou — Tue, 02 Feb 2010 14:37:25 GMT

We've had one or two but found it happened more when they didnt have catheters placed, even though it wasnt going perivascular.
We found if it got cool it seemed to 'thicken up' a bit and we'd get more reactions. Now we warm it gently in our hands if its particularly cold before administering it.