RE: Augmentin

PSA-David — Tue, 11 Oct 2016 11:38:24 GMT

500 mg/100 mg powder for solution for injection or infusion

The reconstituted solution (1 vial with 10 ml of Water for Injections Ph.Eur.) should be used or diluted immediately, within 20 minutes.

1000 mg/200 mg powder for solution for injection or infusion

The reconstituted solution (1 vial with 20 ml of Water for Injections Ph.Eur.) should be used or diluted immediately, within 20 minutes.

Diluted for intravenous infusion

500 mg/100 mg powder for solution for injection or infusion

Chemical and physical in-use stability has been demonstrated for 2-3 hours at 25°C, or 8 hours at 5°C. From a microbiological point of view, the reconstituted and diluted solution (1 reconstituted vial in a minimum volume of 50 ml of infusion fluid) should be used immediately.

1000 mg/200 mg powder for solution for injection or infusion

Chemical and physical in-use stability has been demonstrated for 2-3 hours at 25°C, or 8 hours at 5°C. From a microbiological point of view, the reconstituted and diluted solution (1 reconstituted vial in a minimum volume of 100 ml of infusion fluid) should be used immediately.

Intravenous infusions of amoxicillin/clavulanic acid may be given in a range of different intravenous fluids. Satisfactory antibiotic concentrations are retained at 5 °C and at room temperature (25°C) in the recommended volumes of the following infusion fluids. If reconstituted and maintained at room temperature (25°C), infusions should be completed within the times stated in the table below.

Intravenous infusion	Stability period at 25°C
Water for Injection Ph.Eur.	3 hours
0.9% w/v Sodium Chloride intravenous infusion (9 mg/ml)	3 hours
Compound Sodium Chloride Injection 1959 (Ringer's)	2 hours
Compound Sodium Lactate Intravenous Infusion (Ringer-Lactate:Hartmann's)	2 hours
0.3% w/v Potassium Chloride and 0.9% w/v Sodium Chloride Intravenous Infusion (3 mg/ml and 9 mg/ml)	2 hours

For storage at 5°C, reconstituted solutions of Augmentin IV may be added to pre-refrigerated infusion bags containing either Water for Injection Ph. Eur. or sodium chloride BP (0.9% w/v), which may be stored for up to 8 hours. Thereafter, the infusion should be administered immediately after reaching room temperature.

The stability of Augmentin IV solutions is concentration dependent. In the event that the use of more concentrated solutions is required, the stability period should be adjusted accordingly.

Augmentin IV is less stable in infusions containing glucose, dextran or bicarbonate. Reconstituted solutions of amoxicillin/clavulanic acid may be injected into the drip tubing over a period of 3 to 4 min.

Any residual antibiotic solution should be discarded.

RE: Augmentin

Sal the 1st — Tue, 11 Oct 2016 08:20:17 GMT

I did some research on this at a previous practice - stability is dependant on temperature,concentration and fluid used for reconstitution. If you are using hartmann's to reconstitute it will reduce the stability time by up to 25% because of the bicarbonate,stability is also reduced if dextrans or glucose are present. Depending on concentration, once reconstituted, kept at room temperature it 'may' be stable for up to 4hrs but observe for colour changes and discard if occurs. Refrigerated again dependent on concentration and reconstitution it may remain stable for up to 24 hours.

Makes you wonder (well it does me) just how much medication gets wasted over the course of a year?

RE: Augmentin

Laura Akers RVN — Tue, 11 Oct 2016 01:16:03 GMT

We discard it straight away unless more patients need it at the same time, one place I've worked keeps it an hour in the fridge but if it was my pet, I'd get rid of it I wouldn't want to be giving it more than half an hour X

RE: Augmentin

k.91 — Mon, 10 Oct 2016 23:41:05 GMT

data sheet says can be kept refrigerated for 24 hours.