/b/veterinary-nursing-news/posts/study-links-earlier-gonadectomy-with-higher-cruciate-disease-risk-in-dogs Gonadectomy before 2.9 years of age in female dogs and 2.2 years in males is associated with a substantially increased risk of Cranial Cruciate Ligament Disease (CrCLD), according to new research published in the Journal of Small Animal Practice 1 .en-USTelligent Community 10